具有酸敏特性的阿霉素—叶酸偶联物的制备及其抗肿瘤活性研究

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1、分类号密级国际十进分类号（UDC）第四军医大学学位论文具有酸敏特性的阿霉素-叶酸偶联物的制备及其抗肿瘤活性研究（题名和副题名）叶威良（作者姓名）指导教师姓名周四元教授指导教师单位第四军医大学药学院药剂学教研室申请学位级别硕士专业名称药剂学论文提交日期2012.04答辩日期2012.05论文起止时间2010年08月至2012年04月学位授予单位第四军医大学独创性声明秉承学校严谨的学风与优良的科学道德，本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰

2、写过的研究成果，不包含本人或他人已申请学位或其他用途使用过的成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了致谢。申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：保护知识产权声明本人完全了解第四军医大学有关保护知识产权的规定，即：研究生在校攻读学位期间论文工作的知识产权单位属第四军医大学。本人保证毕业离校后，发表论文或使用论文工作成果时署名单位仍然为第四军医大学。学校可以公布论文的全部或部分内容（含电子版，保密内容除外），可以采用影印，缩印或其他复制手段保存论文。学校有权允许论文被查阅和

3、借阅，并在校园网上提供论文内容的浏览和下载服务。同意学校将论文加入《中国优秀博硕士学位论文全文数据库》和编入《中国知识资源总库》，同意按《中国优秀博硕士学位论文全文数据库出版章程》规定享受相关权益。论文作者签名：导师签名：日期：具有酸敏特性的阿霉素-叶酸偶联物的制备及其抗肿瘤活性研究研究生：叶威良学科专业：药剂学所在单位：第四军医大学药学院药剂学教研室导师：周四元教授关键词：阿霉素；叶酸；pH敏感；氨基己酸；聚乙二醇；靶向药物；肿瘤中国人民解放军第四军医大学2012年5月第四军医大学硕士学位论文目录缩略语表···················

4、·····························································································································1中文摘要················································································································································2

5、英文摘要················································································································································5前言····························································································································

6、····················9文献回顾··············································································································································11正文········································································································

7、······································23第一部分阿霉素-氨基己酸-叶酸偶联物的制备及其抗肿瘤活性研究······························231材料·····························································································································231.1仪器······································

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