不同剂量螺内酯治疗老年慢性心力衰竭的临床研究

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1、英文摘要Onadmission，afteronemonthandsixmonthstreatment，generalitems(height，weight)，heartfunction，electrocardiogram(ECG)，echocardiogram(uce)，6-minutewalkingtest(6MWT)，bloodtest，brainnatriureticpeptide(BNP)，medicinetakingandsideeffectsweremeasuredandevaluated．Theindex(Leftventricularend—diastolicdia

2、meter(LVEDD)，LeftVentricularend—systolicdiameter(LVESD)，Leftventricularend—diastolicvolume(LVEDV)，leftventricularend—systolicvolume(LVESV)andLVEFetc．)ofUCGat1week，1砒monthand6mmonthforpatientsweremeasuredandevaluated，andthedatawerestoredindisk．SPSS11．0softwarepackagewereusedforstatisticalanalys

3、is．Initiallythehomogeneityofvarianceandnormalityamongallthegroupswasanalyzed．Allthemeasurementdataasdenotedbymean4-standarddeviation．Alltheenumerationdatawasexpressedbyfrequencyandpercent．One—wayANOVAwasusedforcompareamonggroupsbeforestudy．Chi—squaretestwasusedforcategoricaldata．Repeatedmeasur

4、esofgenerallinearmodelwasusedforcomparisonamonggroupsatdifferenttimebeforeandaftertreatment．Wetookp<0．05asstatisticalsignificantlevel．Results：1．TheaveragedosageofgroupCwas54．26±16．OOmg／d，groupBwas29．28±5．98mg／dandgroupAwas17．08±3．08mg／d．ThedosageingroupBwasclosetothatinRALEStest(theaverage26mg

5、／d)，SOitcouldberegardedasastandard7英文摘要comparison．2．Therewerenotsignificantdifferenceinsex，age，LVEF,BNPand6MWTamongthethreegroupsbeforestudy．(Table1)3．Intheendofstudy,twopatientsweredeadingroupA，onefromleftfemoralembolismwhichleadtocircularfailure，theotherfromrespiratoryfailureofchronicobstruc

6、tivepulmonarydisease．OnewasdeadingroupB，fromrespiratoryfailure．TwowerelosttocommunicateingroupC．4．TherewerenotsignificantchangesofAlaninaminotransferase(ALT)，Glucose(Glu)，Totalcholesterol(TC)，Triglyceride(TG)andCrinthefirstandsixthmonths．TheserumlevelofK十increasedsignificantat1stmonthingroupCt

7、hanbeforetreatmentp