[英文原版 图形算法] microarray image analysis：an algorithmic approach：1. introduction

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1、1IntroductionFromitsbeginningsinasmallCambridgepubtothemulti-billiondollarindustrythatexiststoday,discoveringthesecretofDNAhastobeoneofthedrivingforcesbehindmodernscientificresearch.Overtheyears,researchintothisillusivecodehastakenmanyforms.Sincetheinitialmappingandopenpublicationofthehuma

2、ngenome,oneofthemostpublicizedapplicationshastobethatofmicroarraytechnologyanditsabilitytofacilitatethemonitoringofmanythousandsofgenessimultaneously.Eventhoughthelandscapeofdataanalysishasbeenseentoevolverapidlyinrecentyears,thebasicdesiretocaptureusefulinformationwithinthedataremainsres

3、ilient.Whatwasonceastrongholdforthestatisticalcommunityhasbeenthrowntothefield;triedandtestedmethodshavefailedtoadapttohighdimensional,undersampleddatawhilstthelargelyapplieddomainofintelligentdataanalysishasbeguntoexcel.Nosinglecommunitycannowstakeaclaimtodominance,asitisbecomingclearerth

4、attheonlywayfor-wardisthroughaunityoftechniques.Techniquesdevelopedforverydiffer-entpurposes,sometimesdecadesbefore,needtoberediscoveredwhilenovelideasaredeveloped.Thechallengenowisinutilizingthissometimesforgottenknowledgeinenvironmentsandwithdatathatisforeigntotheiroriginalap-plication,a

5、swellas,discoveringappropriatetechniquesfromfieldsthatmayhavebeenpreviouslydisassociated.Onlybyfocusingontheircommonality,theinterfacethatwillallowtheuseofatechniquedesignedoriginallyforacompletelydifferentpurpose,inawayneverbeforeenvisioned,canthefullpotentialofnewvastsumsofdatabetrulyreal

6、ized.Thisbookbringstogetherthedisparatefieldsofimageprocessing,dataanalysisandmolecularbiology,alongwithmanyotherstoalesserdegreesuchasoutlierdetection,statisticsandsignalprocessing,allofwhichcapturetheessenceofbioinformatics.HerethefocusisonextractingimprovedresultsfromexistingcDNAmicroar

7、rayexperiments,atechnologythatisstillearlyinitsdevelopment.Themajorityofresearchersinthisfieldrelyonverysimpletechniquesforthefirststagesofanalysisandthenusearangeofstatisticaltechniquestocleanandfilterthedata.Instead,itisproposedthattheseearlystagesarethemostcrucialin