cgrp对骺板生长发育影响与其调控机制的实验分析

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1、英文摘要ExperimentalStudyontheGrowthandDevelopmentofEpiphysealPlateanditsControlMechanismundertheInfluenceofCGRPABSTRACTobjective：Thefunctionofthevertebrateskeletondeterminstheskeletalshapeandsize，buttheydevelopwithgrowthpatternwhichisenchondralboneformation．Epiphysealplateisthedistrictwherethelong

2、bonegrowsactively,also，isthedistrictwhereenchondralbornformation．Thegrowthanddevelopmentofepiphysealplateplaysanimportantroleforthedevelopmentofskeleton．Researchesfindthat，asachiefneuropeptide，CalcitoninGene—RelatedPeptide(CGRP)playsanimportantroleintherepairingandremodelinginfracturehealing．Cl

3、inicsfindthat，theaffectedlimbgrowsslower，whichalwaysturntomalformationandrarefaction，thantheuninjuredsideinthechildrenwithbrachialplexusinjury．buttheinfluenceofperipheralnerveonepiphysealplate’Sgrowthanddevelopmentanditscontrolmechanismneedstobestudiedfurther．Thisresearchintendstoestablishthean

4、imalmodelofthesciaticnerveandfemoralnerveinjuries，andobservethedevelopmentalcapacityoftheepiphysealplatethroughavarietyofphysicalexaminationandobservationundermicroscope，inordertodiscussthefunctionandmechanismthatneuropeptides5英文摘要(takeCGRPforexample)playonthegrowthanddevelopmentofepiphysealpla

5、teafterperipheralnerveinjuries．SOtoprovidesometheoreticalbasisforpromotingthegrowthanddevelopmentoftheaffectedlimbinthechildandyouthwithbrachialplexusinjurybyimprovingneurologicalfunction．Methods：Select40healthyrabbitsaged4--6weeks，bodyweight1．0-1．4kg，maleorfemale，andintroducehomobodyreferencem

6、ethod．Cutthesciaticnerveandfemoralnerveoftheleftlegabout1cmastheexperimentalgroupandtherightlegisn’tcutasthecomparisongroup．Thenalltheexperimentalanimalswereputintothesamecagesaftertheoperation，andfedwithunifiedstandardunderidenticalconditions．Weshouldpayattentiontothetemperatureandinjectpenici

7、lini．m．1pan—unit／kgweightthreedays，twiceeveryday,alsodegermthewoundwithiodophorseverytheotherday,inordertopreventionofwoundinfection．8rabbitsinbothgroupswereselectedrandomlyandkilledbyairembolismtoobservein1,2，4，8weeksaftertheoper