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ID:33733191
大小:4.07 MB
页数:65页
时间:2019-02-28
《cgrp对骺板生长发育影响与其调控机制的实验分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、英文摘要ExperimentalStudyontheGrowthandDevelopmentofEpiphysealPlateanditsControlMechanismundertheInfluenceofCGRPABSTRACTobjective:Thefunctionofthevertebrateskeletondeterminstheskeletalshapeandsize,buttheydevelopwithgrowthpatternwhichisenchondralboneformation.Epiphysealplateisthedistrictwherethelong
2、bonegrowsactively,also,isthedistrictwhereenchondralbornformation.Thegrowthanddevelopmentofepiphysealplateplaysanimportantroleforthedevelopmentofskeleton.Researchesfindthat,asachiefneuropeptide,CalcitoninGene—RelatedPeptide(CGRP)playsanimportantroleintherepairingandremodelinginfracturehealing.Cl
3、inicsfindthat,theaffectedlimbgrowsslower,whichalwaysturntomalformationandrarefaction,thantheuninjuredsideinthechildrenwithbrachialplexusinjury.buttheinfluenceofperipheralnerveonepiphysealplate’Sgrowthanddevelopmentanditscontrolmechanismneedstobestudiedfurther.Thisresearchintendstoestablishthean
4、imalmodelofthesciaticnerveandfemoralnerveinjuries,andobservethedevelopmentalcapacityoftheepiphysealplatethroughavarietyofphysicalexaminationandobservationundermicroscope,inordertodiscussthefunctionandmechanismthatneuropeptides5英文摘要(takeCGRPforexample)playonthegrowthanddevelopmentofepiphysealpla
5、teafterperipheralnerveinjuries.SOtoprovidesometheoreticalbasisforpromotingthegrowthanddevelopmentoftheaffectedlimbinthechildandyouthwithbrachialplexusinjurybyimprovingneurologicalfunction.Methods:Select40healthyrabbitsaged4--6weeks,bodyweight1.0-1.4kg,maleorfemale,andintroducehomobodyreferencem
6、ethod.Cutthesciaticnerveandfemoralnerveoftheleftlegabout1cmastheexperimentalgroupandtherightlegisn’tcutasthecomparisongroup.Thenalltheexperimentalanimalswereputintothesamecagesaftertheoperation,andfedwithunifiedstandardunderidenticalconditions.Weshouldpayattentiontothetemperatureandinjectpenici
7、lini.m.1pan—unit/kgweightthreedays,twiceeveryday,alsodegermthewoundwithiodophorseverytheotherday,inordertopreventionofwoundinfection.8rabbitsinbothgroupswereselectedrandomlyandkilledbyairembolismtoobservein1,2,4,8weeksaftertheoper
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