燥湿泄热法治疗脓毒症湿热蕴脾型胃肠功能障碍的临床研究

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1、提要目的：通过对脓毒症湿热蕴脾型胃肠功能障碍患者的临床观察，探讨燥湿泄热法对本病的临床疗效。方法：将2011年5月至2011年12月山东中医药大学附属医院山东省中医院、山东省千佛山医院急症及ICU收治的符合脓毒症胃肠功能障碍诊断标准，经中医辨证，确定为湿热蕴脾证，确诊符合纳入标准的患者60例纳入研究。研究采用随机、单盲、对照的临床试验设计。入选患者随机分为西医常规治疗加王氏连朴饮组（治疗组）和西医常规治疗组（对照组），于治疗前、治疗后进行中医症状积分和APACHEⅡ评分、降钙素原（PCT）值的检测并进行比较。结果：两组病例症候积分和APACHEⅡ评分与

2、治疗前相比均有所下降，且有显著性差异（P<0.05），与对照组比较，治疗组下降程度显著(P<0.05）；两组病例与治疗前相比PCT值均有所下降，且有显著差异（P<0.05），与对照组比，治疗组下降程度显著（P<0.05）；治疗组有效率高于对照组。结论：燥湿泄热法可以明显改善脓毒症湿热蕴脾型胃肠功能障碍患者的临床症状，控制患者的炎症活动，提高治疗有效率，改善患者预后，具有一定的临床应用价值。关键词燥湿泄热法脓毒症湿热蕴脾型胃肠功能障碍临床疗效Dampnessheatreleasemethodintreatmentofsepsisofdamp-heatre

3、tentionspleentypegastrointestinaldysfunctionclinicalresearchSpeciality:InternalMedicineofTCMAuthor:cuiqiTutor:Prof.KongLiAbstractObjective:Throughtosepsisofdamp-heatretentionspleentypeofgastrointestinaldysfunctioninpatientswithclinicalobservationofdampness,heatreleaselawofthedis

4、easeclinicalcurativeeffect.Methods:In2011Mayto2011DecemberinShandongProvincialTraditionalChineseMedicalHospital,AffiliatedHospitalofShandongUniversityofTraditionalChineseMedicineShandongprovinceQianfoHillhospitalA&EandICUwereconsistentwithsepsisdiagnosiscriterionofgastrointestin

5、aldysfunction,thedifferentiationoftraditionalChinesemedicine,identifiedasdamp-heatretentionspleensyndrome,diagnosedpatientswhomettheinclusioncriteriaof60patientsincludedinthestudy.Thestudyusedarandomized,singleblind,controlledclinicaltrialdesign.Selectedpatientswererandomlydivid

6、edintoroutinetreatmentofWesternmedicinecombinedwithWangevenparkDecoctiongroup(treatmentgroup)andconventionalwesternmedicinetreatmentgroup(controlgroup),beforetreatment,aftertreatmentofTCMsymptomscoreandAPACHEscore,procalcitonin(PCT)valuesofthedetectionandcomparison.Conclusion:Da

7、mpnessheatreleasemethodcanimprovesepsisdamp-heatretentionspleensyndrometypeofgastrointestinaldysfunctioninpatientswithclinicalsymptoms,controlofpatientswithinflammatoryactivity,improvethetreatmentefficiency,reducethemortalityrate,improvethe燥湿泄热法治疗脓毒症湿热蕴脾型胃肠功能障碍的临床研究prognosisofpa

8、tients,withsomeclinicalvalue.KeywordsDampnesshe