血必净注射液对mods患者肺功能的影响研究

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1、提要目的：探讨血必净注射液对多器官功能障碍综合征(MODS)患者的炎性介质、血管外肺水和呼吸功能的影响。方法：选择千佛山医院ICU由各种病因导致的MODS患者41例，随机分为对照组(给予常规西医综合治疗．包括控制感染、支持呼吸功能、维持血流动力学稳定、改善微循环、营养支持及其他脏器支持等治疗)与治疗组(常规西医综合治疗的基础上给予血必净注射液100ml加0.9%生理盐水100ml静脉点滴，每次点滴时间在30分钟至40分钟，每天2次，连用7天)。放置PiCCO导管，监测血管外肺水指数（EVLWI）和胸腔

2、内血容量指数（ITBVI）的变化。记录气道峰压(Ppeak)、肺动态顺应性(Cdyn)和血气分析结果。结果：治疗组治疗后7天，监测炎性介质白介素-6(IL-6)、肿瘤坏死因子（TNF-α）明显降低、EVLWI减少，ITBVI趋向稳定；Ppeak和Cdyn改善，氧合指数明显提高。与对照组比较差异均有统计学意义(p均<0.05)。结论：血必净注射液可以降低炎症介质,减轻MODS患者的血管外肺水，改善呼吸功能,提高抢救成功率。关键词血必净注射液；炎症介质；血管外肺水；呼吸功能EffectsofTheXueb

3、ijinginjectiononoflungfunctioninpatientswithMODSSpeciality:CombinationofChinesetraditionalandWesternMedicineAuthor:WeiZhongliTutor:ProfessorXiejianAbstractObjective：ToinvestigatetheeffectofXuebijingInjectiononinflammatorymediators、extravascularlungwater

4、andrespiratoryfunctioninmultipleorgandysfunctionsyndrome(MODS)。Methods：Forty-oneadultpatientswerechoosedformavarietyofcausesinQianfoshanhospitalwithMODS，randomlydividedintocontrolgroup(giventocompreh-ensivetreatmentofconventionalWesternmedicine，Includin

5、ginfectioncontrol,respir-atorysupport，tomaintainhemodynamicstability，improvemicrocirculation，nutritionalsupport，andotherorgansupporttherapy)andtreatmentgroup(BasedonthecomprehensivetreatmentofConventionalWesternmedicinegiventoXuebijinginjection100mlplus

6、100ml0.9%salineintravenously，everybitoftimein30-40minutes，2timesaday，7days)。PlacementPiCCOcatheter，monitoring,extravascularlungwaterindex(EVLWI)andintrathoracicbloodvolumeindex(ITBVI)changes。Recordpeakairwaypressure(Ppeak)，lungcompliance(Cdyn)andbloodga

7、sanalysis。Results：After7daystreatment，andmonitoringofinflammatorymediatorsinterleukin-6(IL-6)，tumornecrosisfactor(TNF-α)significantlyreduced，EVLWIreduced,ITBVIstabilized。PpeakandCdynimproved，oxygenationindexwassignificantlyimproved。Comparedwithcontrolgr

8、oupdifferenceswerestatisticallysignificant(p<0.05)。Conclusion：Xuebijinginjectioncanreducetheinflammatorymediators,reduceMODSinpatientswithextravascularlungwaterandimproverespiratoryfunction,improvethesuccessrate.KeywordsXuebijing