预防性应用阿托伐他汀对sd大鼠局部脑缺血再灌注后血管内皮功能的影响

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1、术NOS活性明显增强，差异具有显著性统计学意义(P

2、损症状，缩小脑梗死体积，减轻神经细胞变性、坏死及组织水肿，其神经保护作用的机制可能与其增加脑缺血再灌注损伤后VEGF的表达，降低NO的含量和NOS的活性有关。关键词：脑缺血再灌注损伤阿托伐他汀VEGFNONOS3TheinfluenceofendothelialfunctiononprophylacticuseatorVastatlnOnlocalcerebralISChemla-reoerluSlOn■J■ll■l■n●。niury‘SDIninDratlstit’Masterdegreecandidate：ChengZhiyuSupervisor：ProfessorG

3、aoZhengMajor：NeurologyAbstractObjective：ToobservetheexpressionofVEGF，NOSandNOSonfocalcerebralischemia—reperfusioninjuryinSDrats；toobservetheinfluenceoftheexpressionofVEGF，NOSandNOSonprophylacticuseatorvastatinonfocalcerebralischemia—reperfusioninjuryinSDrats；tOdisscusswhetherwithatorvasta

4、tincanrelievetheinjuryofendothelialfunctiononfocalcerebralischemia—reperfusionandpossiblemechanism．Methods：90healthymaleSDrats，accordingtotheprincipleofrandomlydividedintothreegroups(n=30)：sham—operatedgroup，controlgroupandatorvastatincalciumpretreatmentgroup(atorvastatingrouptoabbreviate

5、)，thirtyratsineachgroup．Eachgroupwasdividedinto5subgroupsaccordingtoreperfusion2h(n=6)，6h(n=6)，24h(n26)，48h(n=6)，72h(n=6)afterischemiafor2hours．Atorvastatinregimencontinuedrats，preoperative14daystoatorvastatinregimencontinued(10mg／kg／d)lineirrigationtreatmentstomach，1time／day；sham—operate

6、dgroupandcontrolgroupareinpreoperative14daysinthestomachwithvolumeandO．9％sodiumchloridesolution，1time／day．·UsingtheimprovedLonga·-Zeamethodtoestablishischemia--reperfusionmodelinfightcerebralmiddlearteryofSDrat(eachgroupwasmadeischemia—reperfusionmodelexceptthesham-operatedgroup)．Evaluate

7、theneurologicalimpairmentscorebyreferringtoZea—Longa’Sstandardsoffivegrades；allremovedbrainswasstainedrespectivelywith2％TriphenyTetrazaliumChloride(TTC)；Judgingtheischemiclocation，measuringtheinfarctionpathomorphologythroughHematoxylin—eosin(HE)；observingtheexpressi