应用瑞舒伐他汀对h型高血压大鼠血管内皮功能的影响

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1、授予单位代码10089学号或申请号130%HebeiMedicalUniversity硕士学位论文在职科学学位应用瑞舒伐他汀对H型高血压大鼠血管内皮功能的影响学位申请人：姜金钟导师：王立新教授专业：内科学二级学院：沧州中西医结合医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，实验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。

2、否则，承担相应的法律责任。研究生签字^4^导师签章:河北医科大学研究生学位论文独创声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包括其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签毛导师签章:袁]》脾‘r月V日目录中文摘要·············································································1英文摘要·············································

3、································3英文缩写·············································································6研究论文应用瑞舒伐他汀对H型高血压大鼠血管内皮功能的影响前言·············································································7材料与方法·························································

4、···········8结果·············································································13附图·············································································15附表·············································································18讨论····························

5、·················································19结论·············································································23参考文献·······································································23综述不对称二甲基精氨酸:一种潜在的心血管风险因素············27致谢····································

6、···············································38个人简历·············································································39中文摘要应用瑞舒伐他汀对H型高血压大鼠血管内皮功能的影响摘要目的：探讨通过应用瑞舒伐他汀对H型高血压大鼠的血管内皮生长因子、不对称二甲基精氨酸的影响，探讨其改善血管内皮功能的可能作用机制，为临床应用瑞舒伐他汀提供可靠的实验依据。方法：本实验将大鼠分组：雄性SD大鼠设为正常对照组（NC组）、H型高血压模型对

7、照组（HCY组）、H型高血压大鼠给予瑞舒伐他汀干预组（HR组）及自发性高血压大鼠给予瑞舒伐他汀干预组（SR组），每组8只。H型高血压造模采用自发性高血压大鼠喂食添加2%蛋氨酸的基础鼠粮。HR组和SR组以10mg/kg/d剂量给予瑞舒伐他汀灌胃，其余组大鼠灌服等容量的蒸馏水，连续4周。大鼠在实验期间自由进食水。4周后，内眦静脉采血法测量血清同型半胱氨酸、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇含量。用酶联免疫吸附剂(Enzyme-LinkedImmunosorbentAssay，ELISA)法测量大鼠血清血管内皮生长因子（vascularendot

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