非离子型三碘苯母核造影剂的合成与其造影效果-研究

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1、ABSTRACTMedicalimageology．isplayingamoreandmoreimportantroleinclinicaldiagnosisandscientificreSearCkespeciallythecilinicaldiagnosis，theimagingdiagnosisisirreplaceable．Themainlyimagingdiagnosisprocedureconcludesthefollowingfourtechniques：CT(CompmedTomography)，X-raytransmi

2、ssioncheck,MRI(MagneticResonanceImaging)andUltrasonicInspection．Amongthefourekindsofdiagnosisprocedure，theCTandtheX-raytransmissioncheckiswidelyusedinangiography,urinaryimaging，spinalcordangiographyandSOon．However,thepowerfultransmissionfunctionoftheXraymakesithardtoiden

3、tifythetinydifferenceofdiseasedtissueandordinarytissue，forexamplethedifferenceofangiomaandthebloodvesselishardtotellintheX-rayimage，forthisreasonweneedal(indofdrugthatcallenhancethecontrastradiooftheimage，andthedrugiswhatwecallcontrastmedia．Contrastmediaisakindofdrugused

4、inclinicalimagingdiagnosistostrengthenthecontrastradioandnlaketheimagemorecleartoidentify．Themostpopularcontrastmediausedinclinicaldiagnosisisthenonioniccontrastmediabasedonthetriiodinebenzenebackbone．ThedimertriiodinebenzenebackbonecontrastmediaiSbetterusedinclinicaldia

5、gnosis，butduetothecomplicatedmanufactureprocedure，itscostisSOhilghthattheoperatingfrequencyislimitedinpractice．Wesynthesizedfivenewkindofcontrastmediabasedonthestructure-functionrelationshipinformationandoneofthemcontainsphosphorusgroupinthemolecule．Weinvestigatetheeffic

6、iencyofimagingdiagnosisofthefivecontrastmediacomparedtotwocommercialavailablecontrastmediaIohexolandIovers01．Theresultsuggeststhereisnosignificantdifferencebetweenthefivecompoundswesynthesizedandtwocommercialcontrastmedia．Buttheproduceroutedesignedforthefivecompoundsismo

7、rereasonableandsuitableforindustialmanufacture．Thesynthsisstartsfrom5-aminoiSOphthalicandthefinalcompoundisobtainedaftersixsteps．灿ltheintermediateneedsnopurificationandcanbecrystallizedfromthereactionasthestartingmaterialofthenextproducestep．Besides，weoptimizedproducecon

8、ditionsofawidelyuseddimercontrastmedia-Iodixanolincooperation、析tllpharmaceuticalfactory．Wecombinedthech