下颌前移矫治对osahs兔血浆no肺小动脉的影响

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1、中文摘要与对照组相比变化并不明显；对照组中膜很薄。6．2肺微动脉(d弋<409m)的组织学观察：HE染色较难辨别三组间差别。EVG弹力纤维染色镜下观察发现OSAHS组出现较多的肌性动脉，即肺微动脉有内外两层弹力膜，其间有平滑肌细胞环绕；MAD组大部分肺微动脉仅有一层弹力膜包绕，类似于对照组。。7肌性肺动脉相对中膜厚度的测定：OSAHS组、MAD组及对照组的WT％分别为13．07±O．56％、9．05±0．36％、8．62±0．46％。OSAHS组Ⅵ吓％显著高于MAD组及对照组，有统计学差异(PO．05)。8肺

2、微动脉百分比的测定：OSAHS组、MAD组及对照组肌性动脉和部分肌性动脉占肺微动脉的百分比分别为22．56％、8．75％、7．64％。OSAHS组明显高于MAD组及对照组，有统计学差异(PO．05)。结论：OSAHS可引起兔血浆NO及肺小动脉结构的改变，MAD对OSAHS引起的肺血管结构改变具有预防作用。关键词：阻塞性睡眠呼吸暂停低通气综合征；动物模型；下颌前移矫治器；一氧化氮；肺小动脉k～英文摘要EffectsofMADonNOinPlasmaandSmallPulmonaryArteriesofOSAHSRabbitsA

3、BSTRACTobjective：Throughtheanimalmodelofobstructivesleepapnea-hypopneasyndrome(OSAHS)established，theeffectsofOSAHSandtreatmentofmandibularadvancementdevice(MAD)onnitricoxied(NO)inplasmaandsmallpulmonaryvesselswereobserved．ThisexperimentprovidedtheoreticaltestbasisforclinicalusingMADtotreat

4、OSAHSandtopreventdamagesofthesmallpulmonaryarteries．Method：ThirtymaleNewZealandrabbitsweredividedintothreegroupsatrandom：groupOSAHS，groupMADandcontrolgroup．1％sodiumpentobarbitalwasinjectedintogroupOSAHSandMAD．Onetotwomillilitersmixedcolloidwasinjectedintomuscularismucosaofsoftpalatewhichwa

5、s0．5centimetertotheboundaryofsoftandhardpalate．Thegelwasstoppedinjectinguntilthesubjectsshowedobvioussnoringandapnea．Thecephalometricaldataofsupinepositionshowedtheupperairwaywidthof1／4point，middlepointand3／4pointofsoftpalateweresignificantlydecreasedcomparedwithcontrolgroup．Bloodgasanalys

6、isshowedthatbloodoxygensaturationdecreasedby22％aftermodelestablished．Thosedemonstratedthatanimalmodelhadbeenestablishedsuccessfully．ThengroupMADwerewornmandibularadvanceddevice．Aftertheanimalmodelestablishedsuccessfully,eachgroupwasgiven10％chloralhydrate(5--6ml／kg)throughoralcavityandslept

7、4--6hoursinasupinepositioneveryday．Onthesecondday,cephalometricaldataandbloodgasanalysisofthreegroupswereconductedagainduringsleep．After8weeks，threegroupsofanimalswereanaesthetizedthewithl％pentobarbitalsodium．TwomillilitersbloodWasdrawnfromtheearveintomakeanal