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1、302ISSN100723949ChinJArterioscler,Vol9,No4·实验研究·[文章编号]1007-3949(2001)-04-0302-04钙通道阻断剂与阿斯匹林对肺高压时肺小动脉壁增生的影响1王治平, 曾亚辉, 杨达华(中山医科大学附属第一医院,广东省广州市510080;1.广东省燕岭医院)[主题词]钙通道阻断剂; 阿斯匹林; 肺动脉,高压; 组织增生[摘 要]本实验将新西兰大白兔的左肺动脉与降主动脉进行吻合,环束吻合口近端的左肺动脉,建立单侧动力性肺动脉高压模型。术后用药
2、组兔给饮用大剂量心痛定与小剂量阿斯匹林,并定期测定血中内皮素、血栓素A2/PGI2的浓度变化。观察2～3个月后测肺动脉压及行肺组织病检,发现在形成左→右分流的肺高压兔中,用药组兔虽也行成了肺高压,但肺小动脉壁增生程度明显较肺高压对照组轻,用药组血浆中内皮素的峰值及血栓素A2/PGI2比值也较肺高压对照组低。提示钙阻滞剂+阿斯匹林对肺高压时肺小动脉壁的增生有一定的抑制作用,此种作用可能与药物抑制内皮素及血栓素A2的生成及促进PGI2的形成有一定关系。[中图分类号]R541.1[文献标识码]AThe
3、HyperplasiaofPulmonaryArterioleWallduringPulmonaryHypertensioncanbeIn2terferedbyCalciumChannelBlockingandAspirinWANGZhi-Ping,ZENGYa-Hui,andYANGDa-Hua(TheFirstAffiliatedHospital,SunYatSenUniversityofMedicalScience,Guangzhou510080,China)MeSHCalciumChan
4、nelBlocking;Aspirin;PulmonaryArtery,Hypertension;HyperplasiaABSTRACTAimToobservewhetherthehyperplasiaofpulmonaryarteriolewallduringpulmonaryhypertensioncanbein2terferedbycalciumchannel-blocking.MethodsPerformedtheanastomosisbetweenleftpulmonaryartery
5、anddescendingaortainNewZealandrabbits,andbandedtheproximalleftpulmonaryarteryofanastomosis,toestablishthemodelofone-sidekineticpulmonaryarteryhypertension.Afteroperationrabbitsindruggroupwerefedwithnifedipineandaspirin,andthebloodconcentrationofendot
6、helinandTXA2/PGI2wasmeasuredregularly.Pulmonaryarterypressurewasmeasuredandlungbiopsywasperformedin2-3monthsobservation.ResultsDuringrabbitsformattingpulmonaryhypertension,thosegivingdrugsgotminorhyperplasiaofpulmonaryarteriolewallthanthosenotgivingd
7、rugs.Thebloodconcentrationofendothelinincreasedatallrabbitsbutthecrestvaluewaslowerindrugsgroup.TheratioofTXA2/PGI2waslowerindrugsgrouptoo.ConclusionCalciumchannelblockercaninhibitthehyperplasiaofpulmonaryarteriolewallduringtheformationofpulmonaryhyp
8、ertension,whichcouldbetheresultsthatcalciumchannelblockingandaspirininhibittheproductionofendothelinandTXA2andpromotetheproduceofPGI2. 肺小动脉壁增生是导致肺动脉高压的重要途1.1 实验动物分组径。钙通道阻滞剂在治疗高血压病防止动脉硬化过17只新西兰大白兔,雄性,体重2.0～2.7kg。程中的作用已获肯定,在肺高压的治疗方面也有不随机分为3组,空白对照组(nor
