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ID:32376394
大小:1.32 MB
页数:42页
时间:2019-02-03
《下颌前移矫治对osahs兔血浆no肺小动脉的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中文摘要与对照组相比变化并不明显;对照组中膜很薄。6.2肺微动脉(d弋<409m)的组织学观察:HE染色较难辨别三组间差别。EVG弹力纤维染色镜下观察发现OSAHS组出现较多的肌性动脉,即肺微动脉有内外两层弹力膜,其间有平滑肌细胞环绕;MAD组大部分肺微动脉仅有一层弹力膜包绕,类似于对照组。。7肌性肺动脉相对中膜厚度的测定:OSAHS组、MAD组及对照组的WT%分别为13.07±O.56%、9.05±0.36%、8.62±0.46%。OSAHS组Ⅵ吓%显著高于MAD组及对照组,有统计学差异(PO.05)。8肺
2、微动脉百分比的测定:OSAHS组、MAD组及对照组肌性动脉和部分肌性动脉占肺微动脉的百分比分别为22.56%、8.75%、7.64%。OSAHS组明显高于MAD组及对照组,有统计学差异(PO.05)。结论:OSAHS可引起兔血浆NO及肺小动脉结构的改变,MAD对OSAHS引起的肺血管结构改变具有预防作用。关键词:阻塞性睡眠呼吸暂停低通气综合征;动物模型;下颌前移矫治器;一氧化氮;肺小动脉k~英文摘要EffectsofMADonNOinPlasmaandSmallPulmonaryArteriesofOSAHSRabbitsA
3、BSTRACTobjective:Throughtheanimalmodelofobstructivesleepapnea-hypopneasyndrome(OSAHS)established,theeffectsofOSAHSandtreatmentofmandibularadvancementdevice(MAD)onnitricoxied(NO)inplasmaandsmallpulmonaryvesselswereobserved.ThisexperimentprovidedtheoreticaltestbasisforclinicalusingMADtotreat
4、OSAHSandtopreventdamagesofthesmallpulmonaryarteries.Method:ThirtymaleNewZealandrabbitsweredividedintothreegroupsatrandom:groupOSAHS,groupMADandcontrolgroup.1%sodiumpentobarbitalwasinjectedintogroupOSAHSandMAD.Onetotwomillilitersmixedcolloidwasinjectedintomuscularismucosaofsoftpalatewhichwa
5、s0.5centimetertotheboundaryofsoftandhardpalate.Thegelwasstoppedinjectinguntilthesubjectsshowedobvioussnoringandapnea.Thecephalometricaldataofsupinepositionshowedtheupperairwaywidthof1/4point,middlepointand3/4pointofsoftpalateweresignificantlydecreasedcomparedwithcontrolgroup.Bloodgasanalys
6、isshowedthatbloodoxygensaturationdecreasedby22%aftermodelestablished.Thosedemonstratedthatanimalmodelhadbeenestablishedsuccessfully.ThengroupMADwerewornmandibularadvanceddevice.Aftertheanimalmodelestablishedsuccessfully,eachgroupwasgiven10%chloralhydrate(5--6ml/kg)throughoralcavityandslept
7、4--6hoursinasupinepositioneveryday.Onthesecondday,cephalometricaldataandbloodgasanalysisofthreegroupswereconductedagainduringsleep.After8weeks,threegroupsofanimalswereanaesthetizedthewithl%pentobarbitalsodium.TwomillilitersbloodWasdrawnfromtheearveintomakeanal
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