5—羟色胺1b受体基因(g861c)多态性和抑郁症与帕罗西汀疗效的关联性分析

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1、中文摘要目的：探讨5一羟色胺1B受体(5-HTlB)基因G861C多态性与抑郁症的发病及抗抑郁药帕罗西汀药物疗效之间是否存在相关性。方法：应用聚合酶链式反应(PCR)扩增技术分别测定165例抑郁症患者和160例正常对照者的基因型和等位基因频率，验证不同基因型分布及等位基因频率与抑郁症发病、性别的相关性。同时对145例抑郁症患者进行为期4周的帕罗西汀药物治疗，分别在第1，2，4周进行HAMD评分，计算减分率，用以评定药物疗效。结果：病例组与对照组比较，5-HTlB受体基因G861C基因型分布及等位基因频率比较差异无统

2、计学意义(P>0．05)。按性别分组，病例组和对照组基因型分布及等位基因频率比较差异无统计学意义(P>O．05)。不同基因型患者在治疗前的HAMD评分比较差异有统计学意义(P

3、罗西汀治疗的临床有效性更高。结论：5-HTlB受体(G861C)基因与抑郁症的发病及性别因素可能不存在相关性，与抑郁症的严重程度及帕罗西汀疗效间存在相关性。关键词：抑郁症；5-HTlB受体基因；多态性；帕罗西汀；关联性AbstractObjectiveToexploretheassociationbetween5-HTlBreceptorgeneG861Cpolymorphismanddepressionandtoexaminetherelationshipof5一HT1BreceptorgeneG861Cpoly

4、morphismandadverseeffectofParoxetine．MethodsThegenetypeandallelefrequenciesof165depressionpatientsand160normalpeoplewasanalyzedwithpolymerasechainreaction．145patientsweredeterminedbyParoxetinetreatmentfor4weeksandevaluated、析tllHamiltonRatingScaleofDepression(H

5、AMD)in1,2，4weeks．Drugefficacywasevaluatedbycalculatingthereducedrate．ResultTherewasnosignificantdifferencebetweendepressivepatientsandcontrols(P>0．05)．Groupedbygender，therewasnosignificantdifferencebetweendepressivepatientsandcontrols(P>0．05)．GroupedbyHAMDdegr

6、eebeforetreatment，Therewassignificantdifferenceinpatientswithdifferentgenotypes(P<0．05)．ThedegreeofdepressioninpatientsofGGgenotypeWashigherthanotherones．After4weeksofparoxetinetreatment，HAMDscorewere，dropped．ThereWassignificantdifferenceofthereducingscore(P<0

7、．05)．PatientsofGGgenotypewasmoresensitivewiththetreatmentofParoxetine．AccordingtOthereducedrateofHAMDtoredlytheclinicaleffectivenessofparoxetine，thereWassignificantdifferenceoftheeffectivepowerattheendoftreatment(P<0．05)．TheeffectivepowerofthepatientswithCCgen

8、otypeandCallelewashigherthanothers．ConclusionTherewasnosignificantassociationbetweentheG861Cpolymophismsof5-HTlBreceptorgeneanddisorder．5-HTlBreceptorgeneG861Cpolymorphismwasassoci