回肠末端灌注丁酸钠对腹膜炎脓毒症大鼠肠道与肺脏保护分析

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1、英文论著摘要IlealInfusionofSodiumButyrateAttenuatesIntestineandLungInjuriesinPeritonitisInducedSepsisRatsIntroductionSepsisandsepticshockasmajorchallenges、加tllsignificantmorbidityandmortalityinmodemhospitals．SystemicInflammatoryResponseSyndrome(SIRS)causedbysevereinfectionisthecoremechanismof

2、thesepsis，buttheallconcretepathophysiologicmechanismsisstillpoorlyunderstood．Thelungandintestinearetwoofthemostvulnerableorgansduringsepsis，thereleasedinflammatorymediatorcantriggeranaugmentedimmuneresponse，chemokines，cytokines，whichinjureboththelocalandextraintestinalorgans，finallyincr

3、easingSIRSlevelandresultinginMultipleOrganDysfunctionSyndrome(MODS)．Cecalligationandpuncture(CLP)Wasregardasthemostwidelyusedmodelforexperimentalsepsisandconsideredasthegoldstandardsepsismodelinresearches．Perforationofthececumresultsinbacterialperitonitis，whichthentriggersSIRS，septicsho

4、ckandMODS．So，CLPmodelWaschoicedinOurstudy．Short—chainfattyacid(SCFA)，whichincludebutyrate，propionateandacetate，areorganicacidsproducedfromanaerobicbacteriafermentationofdietaryfiberinintestinallumen．ThemostimportantSCFAproducedisbutyratethathavemanyfunctionsaffectingguthealth．Butyratepr

5、omotestheabsorptionofsodiumandwater,providesenterocyteswitllenergyimmediately,enhancesintestinalepithelialbarrierfunction．Sincethensomeresearchesindicatethatbutyrateadministrationpreventeddamagetothelung，liverandkidneyduringsepsis．Butyrateinlumenmayprotectagainstintestinalinjuryinsepsis

6、，buttoOurknowledgethishasnotbeenstudiedbefore．Andilealadminstrationofbutyrate，whichisamorenaturalanddirectwayhasnotbeenappliedyet．Forthisreasonwedesignedthisstudytodeterminetheroleof5ilealinfusionofsodiumbutyrateinattenuatesintestineandlunginjuriesinsepsis．Methods——、AnimalsandCLPProcedu

7、reThirtytwomaleSprague—Dawleyratsweighting230-260g．Beforethisexperiment，ratswerefedforsevendaysonandietofakindofenteralnutritionalpowderproductionwithoutfiberdieryandgivenfreeaccesstowater．Thepurposeofthissevendayswashoutperiodistominimizetheconcentrationofbutyrateinintestinalt