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ID:32126640
大小:6.02 MB
页数:48页
时间:2019-01-31
《腹腔扩容术治疗猪失血性休克复苏后腹内高压症对肝肾功能的影响-(8209)》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、第三军医人学硕士学位论文veinsincompletelyblocked.The8minipigswererandomlydividedintotheIAVItreatmentgroupandtheshamoperationcontrolgroup.Datawasrecordedbeforeshock,2haftertheinitiationofIAH,and22haftersurgery,26haftersurgery,respectively.1.Intravesicalpressure(IVP):afterthebladderwasevac
2、uated,50mlofphysiologicalsalinewasinjectedintothebladder,thenthesiliconetubewaserected;theverticalheightofthewatercolumnabovethepubicsymphysiswastakenasintravesicalpressurewhenthecolumndeclinedtoasteadylevel;Inferiorvenacavapressure(IVCP):IVCPwasmeasuredwithamulti—functionmon
3、itorviainferiorvenacavacatheter;urinevolumeperhour.2.DXC800automaticbiochemistryanalyzerwasusedtoanalyzeglutamic—oxalacetictransaminease(AST),glutamic—pyruvictransaminase(ALT),urea(Ur),creatinine(Cr)3.EnhancedabdominalCTscanwasappliedtoobservetheappearanceofliverandkidney.The
4、ratiooftheanteroposteriordiameteroftheabdomentOthetransversediameterwasmeasured(measuredatthelevelwheretheleftrenalveincrossestheaortaandexcludingthesubcutaneousfat).Renalthickness,separationoftherenalpelvisandrenalcalyx,renalpelvisdiameterweremeasured,basedonthedataobtainedf
5、romtherightkidney4.Animalsweresacrificedat26haftersurgery,50gofrightlivertissuesandupperl/8oftherightkidneytissuewerereserved,anddividedinto2parts:onepartofspecimenwereweighedandthenplacedina60。Cdryingovenfor3days.Theotherpartofspecimenwerefixedin10%formalin,embeddedinparaffi
6、n,sliced,performedhematoxylin—eosin(HE)staining,andthenobservedunderthelightmicroscopeResults1.TheIAHmodelwassuccessfullyestablishedin8of12minipigs(66.7%),3minipigsdiedduetoarhythmiawhenanesthetized,1duetoportalveinrupture,2duetOhemorrhagicshock.Theaveragebodyweightwas22.9±1.
7、7Kg,withbaselineMAPof18±14·3mmHg.ExsanguinationwasperformeduntilachievingaMAPof50mmHg,withexsanguinationvolumeof648±98m1.Therequiredtimeforachievingsuccessfulanimalmodelwas3.20+0.60h.Twoanimals(maximumIVPof17.6mmHgand19.2mmHg,respectively)showedrectalprolapseandstressurinaryi
8、ncontinence.Theratioof4第三军医大学硕士学位论文anteroposteriordiametertothetrans
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