泛耐药鲍曼不动杆菌感染的高危因素与临床治疗方案探讨

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1、万方数据硕士学位论文goodantibacterialactivityinvitro．ForthetreatmentofXDRAB，certainstudyshowedthatcombinationtreatmentwasbetterthanmedicationalone．AretrospectivereviewwasconductedbyMoonin108patientswithAcinetobacterbaumanniiinfection，amongwhichtherewere83patientswithXDRABinfection．Thereviewpr

2、esentedthattigecyclinewasagoodchoicefortreatmentofhospitalinfectioncausedbyXDRAB．ZhaoJunxidivided73patientsofpneumoniacausedbyXDRABintotwogroups．Andtheresearchgroupreceivedcombinationtreatment(imipenemcombined诵t11cefperazone-sulbactam)，whilethecontrolgroupweretreatedwithcefperazone-

3、sulbactammonotherepy．Theresultshowedthatthecurerateofresearchgroupwashigherthanthecontrolgroup，andmortalitylower．Asabroad-spectrumantibiotic，carbapenemWaseffectiveagainstXDRAB，butabuseofcarbapenemcouldraiseincidenceofXDRABinfections．Polymyxinantibioticsremainedhighlysensitivetoalmos

4、talloftheG-strains．Inrecentyears，manyreportsshowedthatpolymyxinBWaseffectiveagainstinfectioncausedbyMDR-ABorPDR-AB．As2012ChineseA．baumaniiInfectionDiagnosisandPreventionExpertConsensusproposed，thecommonlyusedcombinationregimensweresulbactamorsulbactam-based13-Lactam，orpolymyxinE，ort

5、igecyclinebasedtwodrugscombinations．Whennecessary,threedrugscombinationregimenscouldbeused．ThedomesticstudyoftreatmentofXDRABhavethefollowingcharacteristics：1Theyaredesignedmainlytostudythetreatmentoflowerrespiratorytractinfection，butscarceofothersites(suchasblood，puncturefluid，secr

6、etionandSOon)．2Moststudiesonlycomparetheefficacyoftwoorthreetherapeuticregimens．Thus，therapeuticregimensstudiedarerelativelysingleandCannotprovidebettertreatmentoptionsfordoctors．3Studiesfocusonstatisticaldepartmentratherthanvariousdepartmentsofthewholehospital．Andthequantityofcases

7、studiedislessSOthattheyhavepoorrepresentation．Consideringtheabovecharacteristics，inthis万方数据ABSTRACTretrospectivestudy,658casesofnosocomialinfectionscausedbyA．baumanii(contains235casesofXDRABinfectionsand423casesofnon．XDRABinfections)arestatisticalanalysedfromdifferentdepartmentsofNa

8、nfangHospitalfromJa