泛耐药鲍曼不动杆菌感染的高危因素与临床治疗方案探讨-(11504)

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1、万方数据硕士学位论文goodantibacterialactivityinvitro．ForthetreatmentofXDRAB，certainstudyshowedthatcombinationtreatmentwasbetterthanmedicationalone．AretrospectivereviewwasconductedbyMoonin108patientswithAcinetobacterbaumanniiinfection，amongwhichtherewere83patientswi

2、thXDRABinfection．ThereviewpresentedthattigecyclinewasagoodchoicefortreatmentofhospitalinfectioncausedbyXDRAB．ZhaoJunxidivided73patientsofpneumoniacausedbyXDRABintotwogroups．Andtheresearchgroupreceivedcombinationtreatment(imipenemcombined诵t11cefperazone-su

3、lbactam)，whilethecontrolgroupweretreatedwithcefperazone-sulbactammonotherepy．Theresultshowedthatthecurerateofresearchgroupwashigherthanthecontrolgroup，andmortalitylower．Asabroad-spectrumantibiotic，carbapenemWaseffectiveagainstXDRAB，butabuseofcarbapenemcou

4、ldraiseincidenceofXDRABinfections．PolymyxinantibioticsremainedhighlysensitivetoalmostalloftheG-strains．Inrecentyears，manyreportsshowedthatpolymyxinBWaseffectiveagainstinfectioncausedbyMDR-ABorPDR-AB．As2012ChineseA．baumaniiInfectionDiagnosisandPreventionEx

5、pertConsensusproposed，thecommonlyusedcombinationregimensweresulbactamorsulbactam-based13-Lactam，orpolymyxinE，ortigecyclinebasedtwodrugscombinations．Whennecessary,threedrugscombinationregimenscouldbeused．ThedomesticstudyoftreatmentofXDRABhavethefollowingch

6、aracteristics：1Theyaredesignedmainlytostudythetreatmentoflowerrespiratorytractinfection，butscarceofothersites(suchasblood，puncturefluid，secretionandSOon)．2Moststudiesonlycomparetheefficacyoftwoorthreetherapeuticregimens．Thus，therapeuticregimensstudiedarer

7、elativelysingleandCannotprovidebettertreatmentoptionsfordoctors．3Studiesfocusonstatisticaldepartmentratherthanvariousdepartmentsofthewholehospital．AndthequantityofcasesstudiedislessSOthattheyhavepoorrepresentation．Consideringtheabovecharacteristics，inthis

8、万方数据ABSTRACTretrospectivestudy,658casesofnosocomialinfectionscausedbyA．baumanii(contains235casesofXDRABinfectionsand423casesofnon．XDRABinfections)arestatisticalanalysedfromdifferentdepartmentsofNanfangHospitalfromJa