基于vegfr靶点的肿瘤靶向抑制肽的改造、筛选与鉴定

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1、英文缩写BFCABSACCmcpmCSCysCUDddH，0EFFCSgGGaGlyhH3H—TdRHPLC英文全称英文缩写索引bifunctionalchelatingagentbullserumalbuminconcentrationcentimetercountsperminutecalfserumCysteinecopperAsparaginedoubledistilledH20GlutamicacidPhenylalaninefluorinefetalcalfserumgramGlvcin

2、egalliumGlycinehourHistidine3H—Thymidinehigh—performanceliquidchromatographyHYNIChydrazinonicotinamideIiodineKIsoleucineindiumLvsine中文全称双功能螯合剂牛血清白蛋白浓度厘米每分钟计数小牛血清半胱氨酸铜天冬氨酸双蒸水谷氨酸苯丙氨酸氟胎牛血清克甘氨酸镓甘氨酸小时组氨酸氚标记胸腺嘧啶高效液相色谱法肼基烟酰胺碘异亮氨酸铟赖氨酸keVkgKeVLLysMmAbMAGlMbqmCi

3、MeVmgmlnmlmmmVnMPPBSPETPheQRRCPReRfrpmSSPECTkiloelectronV0ltkilogramkiloelectron—voltLeucineLvsinemol／LmonoclonalantibodyMercaptoacetyltriglycinemegabecquerelmillicurieMillionelectronVoltmilligramminutemillilitermillimetermillivoltnanomolarProlinephosp

4、hatesalinebufferpositionemissiontomographyPhenylalanineGlutamineArginineradiochemicalpurityrheniumrateofflOWrevolutionsperminuteSerinesecond千电子伏千克千电子伏亮氨酸赖氨酸摩尔浓度单克隆抗体巯基乙酰三甘氨酸兆贝克毫居兆电子伏毫克分钟毫升毫米毫伏纳摩尔脯氨酸磷酸盐缓冲液正电子发射断层显像苯丙氨酸谷氨酰胺精氨酸放射化学纯度铼迁移率每分钟转数丝氨酸秒singlepho

5、tonemissioncomputedtomography单光子发射计算断层显像Tctechnetium2锝gCiVVEGFVEGFRYmicrocurieValinevascularendothelialvascularendothelialTyrosinegrowthfactorgrowthfactorreceptor3微居缬氨酸血管内皮生长因子血管内皮生长因子受体酪氨酸Bioinformaticstransformation，screening，oftumorinhibitorypeptide

6、targetingVEGBackgroundsandObjectives：AbstractidentificationFreceptor冰Thegrowth，invasiveness，metastasisoftumorsdependsontumorangiogenesisAnti．．angiogenesishasgoodapplicationprospect．Vascularendothelialgrowthfactor(VEGF)andvascularendothelialgrowthfactor

7、receptor(VEGFR)hasbecomeacrucialtargetofanticancertherapybecauseoftheirfunctionsofanti—angiogenesis．VascularendothelialgrowthfactorasthemajorangiogenesispromotingfactorplayanimportantroleinangiogenesisthroughcombinationwithVEGFreceptor(VEGFR)expressing

8、onthecellmembrane．AmongalltheVEGFR，VEGFR一1(Flt一1)andVEGFR一2(KDR)havehigherexpressionintumorcellsandnewvascularendothelialcells，buthaveextremelylowexpressionorevendon’texpressinothercells．SoVEGFR一1(Flt—1)andVEGFR一2(KDR)areinacoreposition