卵巢癌患者血清ca125水平与临床分期病理类型的相关性研究

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1、卵巢癌患者血清CA125水平与临床分期病理类型的相关性研张春芳(山东省德州市屮医院检验科山东德州253000)【屮图分类号JR737.31L文献标识码】A【文章编号】1672-5085(2012)15-0061-02【摘要】FI的探讨卵巢癌患者血清CA125水平与临床分期病理类型的相关性。方法采用化学发光法检测了62例卵巢癌患者,47例卵巢良性肿瘤患者,50例健康对照者的血清CA125浓度。结果卵巢癌患者血清CA125水平显著高于卵巢良性肿瘤组和健康对照组(P<0.01);卵巢良性肿瘤组血清CA125水平明显高于健康对照组(P<0.05);卵巢癌组患者中，血清CA125水平与

2、肿瘤分期Z间有密切相关性，随着临床分期的增加，血清CA125水平逐渐增加,不同临床分期的卵巢癌患者Z间,血清CA125水平差异有显著性(P<0・01);血清CA125水平与卵巢癌病理类型Z间亦有密切相关性，浆液性显著高于非浆液性(P<0.01)o结论卵巢癌患者血清CA125水平与临床分期病理类型均有密切相关性，血清CA125是卵巢浆液性囊腺癌的首选标志物，对治疗效果监测，判断有无复发、转移具有重要临床价值。【关键词】卵巢癌CA临床分期病理类型化学发光SerumCA125levelsinpatientswithovariancancerandtheclinicalstageof

3、therelevaneeofpathologicaltypes【Abstract]ObjectiveToinvestigatetheserumCA125levelofpatientswithovariancancerhistologicaltypeandclinicalstageofthecorrelation.ChemiluminesceneeDetectionMethods62patientswithovariancancer,47casesofbenignovariantumorpatients,50healthycontrolswereserumCA125concentratio

4、n.ResultsofserumCA125levelsinpatientswithovariancancerweresignificantlyhigherthanbenignovariantumorgroupandthehealthycontrolgroup(P<0.01);ovarianbenigntumorserumCA125levelsweresign讦icantlyhigherthancontrolgroup(P<0.05);ovariancancerpatients,theserumCA125levelsandtumorstagearecloselyrelated,

5、withtheincreaseofclinicalstage,serumCA125levelgraduallyincreased,differentclinicalstagesofovariancanceramongpatientswithserumCA125levelsweresignificantlydifferent(P<0.01);serumCA125levelandalsobetweenthepathologicaltypesofovariancancerarecloselyrelated,weresignificantlyhigherthannon-seroussero

6、us(P<0.01).ConclusionsSerumCA125levelsinpatientswithovariancancerandclinicalstagewerecloselyrelatedtohistologicaltype,serumCA125inovarianserousmarkersofchoicefortreatmentmonitoring,todeterminewhethertherecurreneeandmetastasishasimportantclinicalvalue.【Keywords]ovariancancerclinicalstageandhist

7、ologicaltypeCAchemiluminescenee自1981年Bast等发现了糖类抗原CA125以来，血清CA125检测已被广泛应用于临床，尤其作为上皮性卵巢癌的重要肿瘤标志物，在其诊断、疗效观察、估计复发、评估预后等方面发挥着重要作用。本文检测了62例卵巢癌患者、47例卵巢良性肿瘤患者以及50例健康对照者的血清CA125水平，旨在探讨肿瘤患者的血清CA125水平与临床分期病理类型的相关性，报道如下。1材料与方法1.1一