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1、乙肝HBeAg定量、前S1蛋白及HBV-DNA之间的相关性探讨青岛大学医学院免疫学教研室山东青岛266071【摘要】目的探讨乙肝患者HBeAg定量、前S1蛋白及HBV-DNA之间的相关性。方法乙肝HBeAg定量采用电化学发光免疫法，同时采用荧光定量PCR法检测HBV-DNA,酶联免疫法检测前S1蛋白。结果HBeAg阳性与HBeAg阴性模式屮HBV-DNA阳性率分别为83.5%和45.5%,差异有统计学意义(χ2=23.7,P<0.01),前S1蛋白的阳性率分别为75.0%和36.0%，差异有统计学意义(χ2=19.9,P<0.01)oHBe
2、Ag和前S1蛋白检测模式中，双阴性组，单阳性组和双阳性组之间HBV-DNA阳性率差异均有统计学意义(P<0.01)。HBeAg和前S1蛋白联合检测与HBV-DNA之间的符合率为78.5%。HBeAg与HBV-DNA双阳性的祥本屮，两指标之间成正相关(r=0.392,P<0.01),对HBV-DNA四组间进行两两比较，发现<103组和103-5组HBeAg数值无明显差异(P>0.05),其余各组间差异均有统计学意义(P<0.05)。结论HBeAg、HBV-DNA、前S1蛋闩三者有较好的相关性，HBeAg和前S1蛋白联合检测与HBV-DNA之
3、间符合率较好，且HBeAg含量与HBV-DNA含量之间成正相关。【关键词】乙肝；HBeAg；HBV-DNA；前S1蛋白ComparativeanalysisondetectionresultsofHBVHBeAg,preSl-AgandHBV-DNA[Abstract]ObjectiveTostudythecorrelationbetweenHBeAgandPre-SiandHBV-DNAantigeninhepatitisBpatients.MethodsHepatitisBHBeAgadoptECU,whileusingreal-timePCRtodetectHB
4、V-DNA,enzyme-linkedimmunosorbentassaypre-Slprotein.ResultsThepositiverateofHBV-DNAofHBeAgpositiveandnegativegroupis83.5%and45.5%,thedifferencewasstatisticallysignifican(tχ2=23.7,P<0.01)，thepositiverateofPre-Siproteinisrespectively75.0%and36.0%,thedifferencewasstatisticallysignifi
5、cant(χ2=19.9,P<0.01).HBeAgandpre-Slproteincombineddetection，HBV-DNApositiveratedifferenceswerestatisticallysignificant(P<0.01)betweenthedouble-negativegroup，positivegroupofsingleanddouble-positivegroup.ThecomplianceratebetweenHBeAgandpre-SlproteincombineddetectionandHBV-DNAis7
6、8.5%.ForHBeAgwithHBV-DNAdoublepositivesamples，thereisapositivecorrelationbetweenthetwoindicators(r=0.392,P<0.01),inthefourgroupsofHBV-DNA，thereisnosignificantdifferenceofHBeAglevelbetween<103groupand103-5group(P>0.05)，amongothergroupsdifferenceswerestatisticallysignificant(P<
7、;0.05).ConclusionHBeAg,HBV-DNA,Pre-Slantigenhasagoodcorrelation，thecomplianceratebetweenHBeAgandpre-SlproteincombineddetectionandHBV-DNAisgood，thereisapositivecorrelationbetweenHBeAgwithHBV-DNA.[Keywords]HepatitisBHBeAgHBV-DNApre-Slprotein【中图分类号】RO621.25+6.23【文献标识码】A【文章编号】2096-
