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1、Hhcy对冠脉内皮细胞损伤机制的临床研宄(武警上海总队医院心血管内科上海201103)【摘要】目的：探讨Hhcy等致病因素在冠脉冠脉内皮细胞损伤的机制。方法：木文选择冠心病(CHD)患者121例，根据冠心病临床症状分组，心痛组71例，急性心肌梗塞组50例，选取95例冠状动脉造影等检查为正常健康者作为正常对照组。测定所有受试者同型半胱氨酸(Hey),内皮细胞(EC),内皮素(ET),烟酸，维生素B12等指标。结果：冠脉狭窄患者各组Hey，EC，ET、烟酸，维生素B12等指标随冠脉狭窄程度的改变而改变，狭窄程度愈严重Hey,EC,ET等指标增高越明
2、显(P<0.01)。CHD组Hey,EC,ET等指标较正常对照组显着升高(P<0.05)o研究同时发现血清Hey与EC水平呈正相关(r=0.61);Hey与ET呈正相关(r=0.55),Hey与烟酸呈负相关(r=-0.62),Hey与维牛.素B12呈负相关(「=-0.58)。结论：Hey,EC,ET水平的增高，烟酸，维生素B12水平的降低等因素在冠脉内膜损伤，斑块形成，导致冠脉狭窄有着重要意义。【关键词】同型半胱氨酸；内皮细胞；内皮素；烟酸；维生素B12【中图分类号】R541【文献标识码】A【文章编号】1007-8231(2016)
3、15-0063-02ToinvestigatethemechanismaboutthepathogenicfactorsincludingHhcy,incoronaryarterycoronaryendothelialcelldamagemechanismZhangQjngcheng,ZhangXiangfeng(correspondingauthor),HanXiaodan.DepartmentofCardiology,shanghaiMunicipalCorpsHospital.ChinesePeople’sArmedPolic
4、eForces,201103[Abstract]ObjectiveToinvestigatethemechanismaboutthepathogenicfactorsincludingHhcy,etcincoronaryarterycoronaryendothelialcelldamagemechanism.MethodsInthispaper,accordingtocoronaryangiographyexamination,select121casesofcoronaryheartdisease(CHD)patients.According
5、totheclinicalsymptomofcoronaryheartdiseasegroup,heartachegroup71cases,acutemyocardialinfarctiongroup50cases.95casesofnormalhealthysubjectswereselectedascontrolgroup.TheHey,EC,ET,niacinandvitaminB12weremeasured.ResultsInpatientswithcoronaryarterystenosisgroupsofHey,EC,ET,niac
6、in,vitaminB12indicatorsalongwiththechangeofcoronaryarterystenosisdegreechange,themorethedegreeofstenosisseriousHey,EC,ET,etcindicatorsincreased,themoreobvious,inseverestenosisgroup(P<0.01).Hey,EC,ETinCHDgroupsignificantlyincreasedthanthenormalcontrolgroup.Thestudyalsofoun
7、dthatthelevelofserumHeyandEC,HeyandET,Heyandniacinhadapositivecorrelation(r=0.61,r=0.55,r=0.62).Heyhadniacin,HeyhadvitaminB12hadanegativecorrelation(r=-0.62,r=-0.58).ConclusionsThelevelofHey,EC,ETincreasingandthelevelofniacin,vitaminB12reducinghasimportantsignificanceincoron
8、aryarteryintimalinjury,plaqueformation,leadingtocoronaryarterystenosis.【Key
