黄芪针穴注肾俞阴陵泉对阿霉素肾病大鼠蛋白、血脂的影响

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1、-------ABSTRACTEffectofHuangqiAcupointInjectioninShenshu(BL23)andYinlingquan(BL23)onProteinandLipidemiaofAdriamycin-inducedNephropathyRatsObjectiveToobservetheeffectoftheacupointinjectionwithHuangqiinShenshu(BL23)andYinlingquan(BL23)onthecontentsofurineprotein,Serumalbumin,B

2、UN,TG,TCandkidneymorphologychangesinratswithAdriamycin-inducedNephropathy,soastoprovethepossibilityofthisteatmentmethod.MethodsThehealthySDratswereintravenousinjectedwithAdriamycintoinduceAdriamycinNephropathyRatsinadditiontothatofthenormalgroupwithsalin.TheHuangqidoubleacup

3、ointsinjectiongroupandthedoubleacupointsinjectionwithsalingroupwereinjectedinShenshu(BL23)andYinglingquan(BL23);TheHuangqisingleacupointinjectiongroupwasinjectedinShenshu(BL23);Thedruggroupwasfedwiththesolutionoftabletsoftripterygiumwilfordiiintothestomach.Toobservethekidney

4、morphologyandhistologychangesanddetectthecontentsofurineproteinwithin24hoursbeforeandafter14dtheinjectionofAdriamycin,andtheurineproteinwithin24hours,SerumALB,BUN,TGandTCafter14dtreatment.Results(1)Theurineproteinquantitativewithin24hoursweresignificantlydecreasedbyallthetre

5、atments,espesciallythetripterygiumwilfordiiandhuangqidoulbeacupointsinjection(P<0.01).(2)Thetreatmentshadthesamefunctions,butthehuangqidoubleacupointsandsingleacupointinjectionshowedmoreeffectivetoimprovethecontentsofserumALBandreducetheTGandTC(P<0.01).(3)Allthegroupstreated

6、showedbetterresultsinbehaviorandhistomorphology.ConclusionsThetreatmentofhuangqiacupointsinjectioninShenshu(BL23)andYinlingquan(BL23)candecreasethecontentsofurineproteinwithin24hours,TGandTCofserum，increasethatofserumALBandimprovethebehaviorandhistomorphologyofratswithAdriam

7、ycin-inducedNephropathySubjectWordsHuangqiInjection,AcupointInjection,AdriamycinNephropathy-----------万方数据-----------前言肾病综合征不是一个独立的疾病，而是许多疾病过程中，损伤肾小球毛细血管滤过膜通透性，血浆蛋白的滤过增加，引起大量蛋白尿而发生的一个症候群。临床主要表现为大量蛋白尿（>3.5g/d）、低蛋白血症(血浆白蛋白<30g/L)、伴有或不伴血脂升高、水肿[1]。肾病综合征的病因可能与感染及变态反应等因素有关，目前被认为是由

8、异常T淋巴细胞克隆介导的一种与免疫反应有关的疾病[2]。肾病综合征是肾小球疾病的特征，肾小球电荷屏障和机械屏障损伤，基底膜通透性增加而导致大量蛋白质从