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1、授予单位代码10089学号或申请号20153333中国图书分类号R563.9HebeiMedicalUniversity硕士学位论文专业学位急性呼吸窘迫综合征的免疫调节治疗研究生：陈海利导师：田凤军副教授专业：内科学二级学院：第三医院2018年3月目录中文摘要················································································1英文摘要··········································
2、······································2英文缩写···········································································3综述急性呼吸窘迫综合征的免疫调节治疗···································5致谢··················································································
3、·21个人简历···············································································22中文摘要急性呼吸窘迫综合征的免疫调节治疗摘要急性呼吸窘迫综合征(Acuterespiratorydistresssyndrome，ARDS)发生时，体内免疫细胞被过度激活，导致肺部炎症瀑布反应，肺组织在强烈的炎症反应攻击下，肺上皮细胞及血管内皮细胞完整性被破坏，造成肺水肿、肺泡出血及生成透明膜等一系列改变。ARDS发病机制复杂，炎症反应
4、贯穿始终。树突状细胞、间充质干细胞、促红细胞生成素以及一些药物，如他汀类、肝素、乌司他丁、中药类可以通过免疫细胞、信号传导通路介导的基因表达等免疫调节方式改善肺部紊乱的炎症反应，为ARDS的治疗提供前景。关键词：急性呼吸窘迫综合征，发病机制，炎症反应，免疫调节，治疗1英文摘要ImmunotherapyforacuterespiratorydistresssyndromeABSTRACTWhenacuterespiratorydistresssyndromeoccurs,theimmunecellsoftheb
5、odyareexcessivelyactivated,causinginflammatorycascadereactioninthelung.Becauseofthisintenseinflammatoryresponseagainstlungtissue,theintegrityoflungepithelialcellsandvascularendothelialisdestroyed,leadingtoaseriesofchangesofpulmonaryedema,alveolarhemorrhagea
6、ndformationoftransparentfilm.PathogenesisofARDSiscomplex,andtheinflammatoryresponseisthroughoutinthisprogress.Dendriticcells,mesen-chymalstemcells,erythropoietinandsomedrugssuchasstatins,heparin,ulin-astatin,Chinesemedicinecanimprovetheinflammatoryresponseo
7、flungindisorderbyimmunemediatemethodsofimmunecells,geneexpressionmedi-atedbysignalingpathwayswhichprovideprospectsforthetreatmentofacuterespiratorydistresssyndrome.Keywords:Acuterespiratorydistresssyndrome,Pathogenesis,Inflam-mat-oryresponse,Theimmuneregula
8、tion,Treatment2英文缩写英文缩写英文缩写英文全称中文全称ARDSAcuterespiratorydistresssyndrome急性呼吸窘迫综合征ECMOExtracorporealmembrane体外膜肺氧合oxygenationTNF-αTumornecrosisfactor-alpha肿瘤坏死因子-αILInterleukin白细胞介素DCsDendriticcells树突状细胞
