mthfr基因c677t和a1298c多态性与亚洲地区男性不育症相关性的meta分析

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1、授予单位代码10089学号或申请号20153246中国图书分类号R698+.2HebeiMedicalUniversity硕士学位论文专业学位MTHFR基因C677T和A1298C多态性与亚洲地区男性不育症相关性的meta分析研究生：秦通导师：王亚轩教授专业：外科学二级学院：第二医院2018年3月目录中文摘要···········································································································1英文摘要···························

2、················································································2英文缩写···········································································································4研究论文MTHFR基因C677T和A1298C多态性与亚洲地区男性不育症相关性的meta分析前言·····················································

3、······················································5材料与方法·······························································································6结果·········································································································8附图····························

4、··············································································10附表··········································································································19讨论······································································································

5、····22结论··········································································································24参考文献·································································································24综述亚甲基四氢叶酸还原酶(MTHFR)基因多态性与男不育····················30致谢·······················

6、··························································································40个人简历·········································································································41中文摘要MTHFR基因C677T和A1298C多态性与亚洲地区男性不育症相关性的meta分析摘要目的：为了评估亚洲地区亚甲基四氢叶酸还原酶(methy-lenetetra-hydro

7、folatereductase,MTHFR)基因C677T(rs1801133)和A1298C(rs1801131)多态性是否与男性不育易感性有关。方法：从建库到2018年01月，在PubMed、中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方、维普数据库中按关键词全面搜索，选择含有C677T和A1298C可用基因型频率的病例对照研究。运用Stata12.0软件进行meta分析。结果：有22篇C677T（5333例和4596例对照）和11篇A1298C（2