肠易激综合征动物模型的研究进展

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1、［摘要］肠易激综合征(IBS)是一种功能性肠病，其病因及发病机制尚未完全阐明。目前临床上的主要治疗原则仍是对症治疗。关于IBS动物模型的研宄有很多，最常用实验动物是大鼠与小鼠。模型构建方法较多，有物理化学刺激、心理应激、药物致泻、病原体感染、复合方法及其他方法等。观测指标包括一般情况、肠道敏感性测试、肠道转运功能、病理学检查、相关脑肠肽的检测等。现在的动物模型大多仅从病理生理机制中的某一方面着手，而IBS的发病机制复杂，诱发因素个体化、多样，因此目前的动物模型均具有不同程度的局限性，还需进一步研究。本文拟对IBS动物模型研究进展作一综述。［关键词］肠易激综合征；动物模型；建

2、模方法;观测指标［中图分类号］R574［文献标识码］A［文章编号］1673-7210(2016)09(c)-0047-04［Abstract］Irritablebowelsyndrome(IBS)isakindoffunctionalboweldisease，anditsetiologyandpathogenesishasnotbeenfullyelucidated.Atpresent，themaintreatmentprincipleisstillsymptomatictherapy.TherearealotofresearchesonIBSanimalmodel，inw

3、hichratsandmicearethemostcommonlyanimalsused.Modelconstructionmethodsaresomany,suchasphysicalandchemicalstimulation，psychologicalstress，druginduceddiarrhea，pathogeninfection，compoundmethodandothers.Theobservationindexesincludedgeneralsituation，intestinalsensitivitytest，intestinaltransitfun

4、ction,pathologicalexamination，andthedetectionofrelatedbraingutpeptide.Animalmodelnowproceedonlyfromacertainaspectofpathophysiologicalmechanism,howeverthepathogenesisofIBSiscomplex,inducingfactorsindividualanddiversified.Socurrentanimalmodelhaslimitationstosomeextent，andneedfurtherstudy.Thi

5、spaperaimstoreviewtheresearchprogressonanimalmodelofIBS.[Keywords]Irritablebowelsyndrome；Animalmodel；Modelconstructionmethods；Observationindexes肠易激综合征(irritablebowelsyndrome，IBS)themaintreatmentprincipleisstillsymptomatictherapy.TherearealotofresearchesonIBSanimalmodel，inwhichratsandmicear

6、ethemostcommonlyanimalsused.Modelconstructionmethodsaresomany,suchasphysicalandchemicalstimulation，psychologicalstress，druginduceddiarrhea，pathogeninfection，compoundmethodandothers.Theobservationindexesincludedgeneralsituation，intestinalsensitivitytest，intestinaltransitfunction,pathologica

7、lexamination，andthedetectionofrelatedbraingutpeptide.Animalmodelnowproceedonlyfromacertainaspectofpathophysiologicalmechanism,howeverthepathogenesisofIBSiscomplex,inducingfactorsindividualanddiversified.Socurrentanimalmodelhaslimitationstosomeextent，andneedfur