盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床研究

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1、中国骨肿瘤骨病2009年8月第8卷第4期ChinJBoneTumor&BoneDisease,August2009,Vol8,No.4.229..论著.盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床研究魏力利　卢卫忠　胡志芬作者单位：400013，重庆市中山医院骨科(魏力利)，重庆市中医院骨科(卢卫忠，胡志芬)【摘要】　目的　观察盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床疗效。方法　354例膝骨性关节炎患者随机分为盐酸氨基葡萄糖组(A组)、外用中药组(B组)和盐酸氨基葡萄糖+外用中药组(C组)。A组为口服盐酸氨基葡萄糖，１粒/次，２次/d，疗程６周；B组中药骨痹痛外敷散外用，１次

2、/2d，15次为１个疗程；C组为在A组基础上同时加用B组方法。结果　C组在改善行走疼痛、夜间静息痛、晨僵方面优于A组和B组，A组又优于B组，差异有统计学意义(P＜0.05)。总有效率A组79.65%，B组67.28%，C组89.38%，差异有统计学意义(P＜0.05)。出现不良反应A组３例、B组３例、C组４例，均较轻微，无严重不良事件发生。结论　盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎安全、有效，联合应用时疗效进一步增强。【关键词】　骨关节炎；临床试验；氨基葡萄糖；中药doi:10.3969/j.issn.1671-1971.2009.08.011Glucosaminehydroch

3、loridecombinedwithexternallyappliedChinesetraditionalmedicineinthetreatmentofkeeosteoarthritisWEILili,LUWeizhong,HUZhifen.DepartmentofOrthopedics,ZhongshanHospitalofChongqing,Chongqing,400013,China【Abstract】ObjectiveToobservetheefficacyofglucosaminehydrochloridecombinedwithexternallyappliedChin

4、esetraditionalmedicineinthetreatmentofkneeosteoarthritis.MethodsAtotalof354patientswithkneeosteoarthritisweredividedrandomlyintothreegroups:theglucosaminehydrochloridegroup(groupA),theexternallyusedChinesetraditionalmedicinegroup(groupB),andtheco-treatmentwithglucosaminehydrochlorideandexternal

5、lyusedChinesetraditionalmedicinegroup(groupC).PatientsingroupAorallytookglucosaminehydrochloridetwicedailyfor6weeks,with1capsuleeachtime.PatientsingroupBweretreatedwithexternallyusedChinesetraditionalmedicineonceeveryotherdayfor15times.PatientsingroupCwereco-treatedwiththemethodsofgroupAandB.Re

6、sultsThesymptomaticimprovementofjointpainatwalking,atrestandstiffnessaftertreatmentinthegroupCwasmoreobviousthanthoseinthegroupAandB,andtheseresultsingroupAwasbetterthanthoseingroupB.Therewassignificantdifferencebetweenthesethreegroups(P＜0.05).ThetotaleffectiverateingroupA,groupBandgroupCwas79.

7、65%，67.28%and89.38%respectively.Therewasstatisticaldifferencesignificantlybetweenthreegroups(P＜0.05).Adversereactionpresentedin3patientsingroupAandgroupBrespectively,and4ingroupC.Alladversereactionwasmild.ConclusionsGlucosaminehyd