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ID:18040351
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时间:2018-09-13
《盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中国骨肿瘤骨病2009年8月第8卷第4期ChinJBoneTumor&BoneDisease,August2009,Vol8,No.4.229..论著.盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床研究魏力利 卢卫忠 胡志芬作者单位:400013,重庆市中山医院骨科(魏力利),重庆市中医院骨科(卢卫忠,胡志芬)【摘要】 目的 观察盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎的临床疗效。方法 354例膝骨性关节炎患者随机分为盐酸氨基葡萄糖组(A组)、外用中药组(B组)和盐酸氨基葡萄糖+外用中药组(C组)。A组为口服盐酸氨基葡萄糖,1粒/次,2次/d,疗程6周;B组中药骨痹痛外敷散外用,1次
2、/2d,15次为1个疗程;C组为在A组基础上同时加用B组方法。结果 C组在改善行走疼痛、夜间静息痛、晨僵方面优于A组和B组,A组又优于B组,差异有统计学意义(P<0.05)。总有效率A组79.65%,B组67.28%,C组89.38%,差异有统计学意义(P<0.05)。出现不良反应A组3例、B组3例、C组4例,均较轻微,无严重不良事件发生。结论 盐酸氨基葡萄糖和中药外敷治疗膝骨性关节炎安全、有效,联合应用时疗效进一步增强。【关键词】 骨关节炎;临床试验;氨基葡萄糖;中药doi:10.3969/j.issn.1671-1971.2009.08.011Glucosaminehydroch
3、loridecombinedwithexternallyappliedChinesetraditionalmedicineinthetreatmentofkeeosteoarthritisWEILili,LUWeizhong,HUZhifen.DepartmentofOrthopedics,ZhongshanHospitalofChongqing,Chongqing,400013,China【Abstract】ObjectiveToobservetheefficacyofglucosaminehydrochloridecombinedwithexternallyappliedChin
4、esetraditionalmedicineinthetreatmentofkneeosteoarthritis.MethodsAtotalof354patientswithkneeosteoarthritisweredividedrandomlyintothreegroups:theglucosaminehydrochloridegroup(groupA),theexternallyusedChinesetraditionalmedicinegroup(groupB),andtheco-treatmentwithglucosaminehydrochlorideandexternal
5、lyusedChinesetraditionalmedicinegroup(groupC).PatientsingroupAorallytookglucosaminehydrochloridetwicedailyfor6weeks,with1capsuleeachtime.PatientsingroupBweretreatedwithexternallyusedChinesetraditionalmedicineonceeveryotherdayfor15times.PatientsingroupCwereco-treatedwiththemethodsofgroupAandB.Re
6、sultsThesymptomaticimprovementofjointpainatwalking,atrestandstiffnessaftertreatmentinthegroupCwasmoreobviousthanthoseinthegroupAandB,andtheseresultsingroupAwasbetterthanthoseingroupB.Therewassignificantdifferencebetweenthesethreegroups(P<0.05).ThetotaleffectiverateingroupA,groupBandgroupCwas79.
7、65%,67.28%and89.38%respectively.Therewasstatisticaldifferencesignificantlybetweenthreegroups(P<0.05).Adversereactionpresentedin3patientsingroupAandgroupBrespectively,and4ingroupC.Alladversereactionwasmild.ConclusionsGlucosaminehyd
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