白药膏外敷治疗膝骨性关节炎的临床疗效观察

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1、目录中文摘要············································1英文摘要·············································2引言···············································4正文··············································61.临床资料·········································61.1观察对象·········

2、·································61.2诊断标准·············································71.3临床观察病例纳入标准······························91.4临床观察病例排除标准·······························91.5临床病例的剔除与脱落························〃91.6膝关节功能评价标准·····························91.7临床疗效

3、评定标准······························91.8安全性评价······································101.9治疗方法······································101.10统计方法······································112.临床观察结果······································112.1治疗前后比较·····························

4、········112.2两组病例临床疗效比较···························122.3两组病例的HSS膝关节功能评分结果················122.4两组病例用药安全性比较··························142.5两组病例用药后起效时间比较············143.讨论················································143.1膝骨性关节炎的相关理论及治疗原则············143.1.1中医膝OA病因病机及

5、治疗的认识···············153.1.2现代医学的认识及作用机理················2711.存在的问题和展望·································31结论···········································32参考文献··········································33附录··············································37综述··············

6、·····························39致谢··········································45攻读学位期间发表的学术论文目录·····················47作者声明···········································48个人简历············································492中文摘要目的：通过观察白药膏外敷与透明质酸钠关节腔内注射的方法对比治疗早、中期膝骨性关节炎（KOA

7、），并对临床症状、体征的改善情况做以分析，初步阐明此方法防治膝骨性关节炎的机理，为中西医临床运用提供一定的依据。方法：根据病例的纳入与排除标准（西医及中医诊断标准），选择80例膝骨性关节炎患者随机平均分为治疗组和对照组。治疗组对患者膝关节及其周围组织运用白药膏外敷治疗每3天外敷一次，外敷5周为一个疗程；对照组在无菌操作下，行膝关节腔内单独注射透明质酸钠，每周一次，5周为一个疗程。疗程结束后，两组病人每周复查，以三个月为观察期，治疗结束后通过患者的症状及体征判断治疗效果。结果：1.两组患者治疗前后疗效比较：根据临床疗效评定标

8、准的结果及治疗前后的HSS膝关节功能评分，对照组40例中治愈10例（25.0%），显效16例（40.0%），有效6例（15.0%），无效8例（20.0%），总有效率1.%。治疗组40例中治愈12例（30.0%），显效15例（37.5%），有效7例（17.5%），无效6例（15.0%），总有效率85.0%