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1、贵阳中医学院2007届硕士研究生学位论文ABSTRACTObjective:EstablishmentofAdriamycin(ADR)nephropathymodelinrat，theresearchLingxiaoDecoctiontoAdriamycin(ADR)nephropathyrat’spharmacologicaleffects,expoundsitspreliminarymechanisms,andprovidesthescientificbasisforthissideclinicalextendedapplication。
2、Methods:Randomlychooses10from50wistarratstotakethenormalgroup,other40usesAdriamycinmakesthenephrosissynthesistodrafttheanimalmodel,Againrandomlydividesinto4groups,namelythemodelgroup,theLingxiaoDecoctiongroup,thehormonegroup,LingxiaoDecoctionandhormonegroup,eachgroupof10。Then
3、ormalgroupandneproticsyndromegroupwasgiven0.9%NaCl,hormonegroupwasgivenprednisone,LingxiaoDecoctiongroupwasgivenLingxiaoDecoction,LingxiaoDecoction+hormonegroupwasgivenLingxiaoDecoctionandprednisone,thenormalgroupweretreatedwithsalineofthesamevolume.Andinexperimentfront,creat
4、emodellast1week,givesmedicinelast1week,2week,4weekcheckthecontentsof24-hoururineprotection,Andtocheckingtotalglycerol,albumin,totalglycero,totalcholesterol,serumcreatine,ureanitrogen,interlukin-8,nitrogenoxidation,superoxidedismutaseandkidneypathologywhentheexperimentisoverRe
5、sults:1.Generalcircumstance:Duringtheexperiment,normalgroupratfoodanddrink,activityareregular,Themodelgroupratmakesamodelappetiteappearingonthequeenfallingoff,thespiritislanguorous,isurine,thefourlimbsedemaetc.short,stepstateappearsonlaterstagenotstabilizing,failureappearance
6、;Respectively,theappetitecuringgrouplaterstageincreasesbytosomeextent,urineamountsincreasebyrelatively,theactivityisgood,thefourlimbsedemaeasesoff.2.Beforemakingamodeleverygrouprat24-hoururineprotectionhasnodifference(P>0.05).Aftermakingamodel,themodelgrouprat24-hoururineprot
7、ectionovertopsthenormalgroupobviously(P<0.01).14dayand28daycuringlater,themodelgrouprat24-hoururineprotectionstillcontinuesincreaseby,butLingxiaoDecoctiongroup,hormonegroupandLingxiaoDecoction+hormonegroupallareobviousdecrease,Haveobviousdifferencecomparedwithmodelgroup(P<0.0
8、5orP<0.01).3.Whentheexeperimentisover,everymakesthemodelgroupsermtot
