rho rock信号通路在原发性高血压肾纤维化中作用（the rho rock signaling pathway plays a role in primary hypertensive renal fibrosis）

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1、rhorock信号通路在原发性高血压肾纤维化中作用（Therhorocksignalingpathwayplaysaroleinprimaryhypertensiverenalfibrosis）Therho/rocksignalingpathwayplaysaroleinprimaryhypertensiverenalfibrosisArticle:http://www.xzbu.com/[abstract]objectivetoexploretheroleofrho/rocksignalingpathwayinprimaryhypertensiverenalfibrosis.M

2、ethods31casesofprimaryhypertensionpatients,onthebasisofthe24hurinetracealbuminexcretionrate(uaer)dividedintoistemperamentalpredominancealbuminuriagroup(groupa)11cases,tracealbuminuriagroup(groupb)10caseswithuremiagroup(groupc)10cases,10casesofnormalphysicalexaminationisselectedascontrolgroup,

3、themethodofenzymelinkedimmunosorbent(elisa)todetermineeachgroupserumlevelsoftransforminggrowthfactorbeta(TGF?Beta),matrixmetalloproteinase9(MMP?9)andrhocorrelationwithcurlyspiralproteinkinase1(rock?1)level,analysisofTGF?Beta,MMP?9,arock?Thecorrelationbetweenthepatternsofexpressionineachgroupa

4、ndthethree.Resultscomparedwiththecontrolgroup,a,bandcTGF?Beta,MMP?9,arock?Theserumconcentrationincreasedsignificantly(f=14.498~126.037,q=3.222~20.617;p<0.05,0.01);B,groupcTGF?Betaandrock?Theserumconcentrationwassignificantlyhigherthanthatofgroupa(q=4.797~17.636,p<0.01),andbandcgroupTGF?Beta,a

5、rock?Therewasnosignificantdifferenceinserumconcentration(q=0.612,1.175,pBBB00.05).GroupbMMP?Theserumconcentrationincreasedsignificantly(q=4.799,5.959,p<0.01),andtherewasnosignificantdifferencebetweengroupaandgroupc(q=1.299,pBBB00.05).SerumTGF?BetaandMMP?9,TGF?Betaandrock?1,MMP?9andtherock?The

6、correlationbetween1concentrationwaspositive(r=0.381~0.652,p<0.05).Conclusiontherho/rocksignalingpathwaymaybeinvolvedintheprocessofhypertensiverenalfibrosis.[keywords]kidney;Fibrosis;Highbloodpressure.Rho/rocksignalingpathways;Transformationofgrowthfactorbeta;Matrixmetalproteinenzymes[abstract

7、]objectivetoinvestigatetheeffectofrho/rocksignalingpathwayonrenalfibrosisinprimaryhypertension.Onepatientswithprimaryhypertensionweredividedintonormal.Proteinuriagroup(groupa,11cases),microalbuminuriagroup(groupb,10)anduremicgroup(groupc,10)-