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1、参芪扶正注射液对慢性心力衰竭患者血浆N末端脑钠肽前体的影响?1774?P3『CCPVDOctober201l,Vol.19No.10?中药?中西医结合?参芪扶正注射液对慢性心力衰竭患者血浆N末影响王琳,叶炳华,王东兴,李伯堂端脑钠肽前体的【摘要】目的观察参芪扶正注射液对慢性心力衰竭(CHF)血浆N末端脑钠肽前体(NT—proBNP)的影响及临床疗效.方法CHF患者63例,随机分为治疗组(32例)和对照组(31例).对照组给予利尿剂,硝酸酯类药物,血管紧张素转化酶抑制剂或血管紧张素受体拮抗剂,13一受体阻滞剂,洋地黄制剂等常规
2、治疗.治疗组在对照组常规治疗的基础上加用参芪扶正注射液静脉滴注,1次/d,共14d,观察治疗前后两组患者左心功能的改变及血浆NT—proBNP变化.结果治疗后两组左室射血分数及临床表现均明显改善,血浆NT—proBNP均明显下降,但均以治疗组更为显着(P均<0.05).结论在CHF治疗中常规治疗基础上加用参芪扶正注射液可显着降低其血浆NT—proBNP水平,改善左心室功能,增强治疗效果.【关键词】参芪扶正注射液;心力衰竭;血浆N末端脑钠肽前体;左室射血分数【中图分类号】R541.6【文献标识码】B【文章编号】1008—
3、5971(2011)10—1774—02EffectsofShenqifuzhengInjectiononPlasmaNTerminalPro—brainNatriureticPeptideinPatientswithChronicHeartFailureWANGLin,YEBing—hua,WANGDong—Xing,eta1.DepartmentofCardiology,thePe~leSHospitalofTalzhouGaogang,Taizhou225321,China【Abstract】ObjectiveToob
4、servetheeffectclinicalefficacyofShenqifuzhenginjectiononplasmaNterminalpro—brainnatriureticpeptide(NT—proBNP)inpatientsWithchronicheartfailure(CHF).Methods63patientswithCHFwererandomlydividedintotreatmentgroup(n=32)andcontrolgroup(n=31).Controlgroupwasgivendiuretic
5、s,nitrates,an—giotensinconvertingenzymeinhibitorsorangiotensinreceptorblockers,p—blockers,digitalispreparationsandotherconvention—altreatment.Basingonconventionaltherapy,thetreatmentgroupreceivedShenqifuzhengintravenousinjectiononceadayfor14days.Leftventricularfunc
6、tionandplasmaNT—proBNPwereobservedbeforeandaftertreatment.ResultsAftertreatment.1eftventricularejectionfractionandclinicalmanifestationswereimproved,plasmaNT—proBNPweresignificantlydecreased,butthetreatmentgroupweremoresignificant(Pall<0.05).ConclusionBasingonTh
7、econventionaltreatmentofCHFthera—PY,Shenqifu—zhenginjectioncansignifieandyreducetheplasmaNT—proBNPlevels,improveleftventricularfunction,andenhancetreatment.【Keywords】Shenqifuzhenginjection;Heartfailure;PlasmaNterminalpro—brainnatriureticpeptide;Leftventric—ularejec
8、tionfraction作者单位:225321江苏省泰州市高港人民医院心内科(王琳,叶炳华),检验科(王东兴),心超室(李伯堂)慢性心力衰竭的发病率正逐步升高,是心脏病患者住院率增高及后期死亡的重要原因,如何防止和延缓心力衰竭的发展,减少住院率及降低死亡率是当今医学研究的重点之一一,为寻求
