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ID:6387119
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时间:2018-01-12
《代谢综合征患者血清内脏脂肪素和肾功能变化的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、代谢综合征患者血清内脏脂肪素和肾功能变化的相关性研究【摘要】 目的研究代谢综合征(MS)患者血清内脏脂肪素(Visfatin,简称内脂素)和肾功能的变化;并分析它们之间的内在联系。方法以85例MS患者和88例正常对照为研究对象,MS患者按GFR≥90ml·min-1·1.73m-2和GFR<90ml·min-1·1.73m-2分为两组,记录并检测临床和生化指标,采用酶联免疫法检测血清内脂素水平,MDRD公式法计算肾小球滤过率(GFR)。结果MS组和对照组年龄性别匹配。与对照组比较,MS组患者血清内脂素(对数值)和肌酐水平显著升高〔(1.06
2、±0.16)vs(0.98±0.25)ng/ml,P<0.05;(73.20±13.95)vs(63.93±13.78)μmol/L,P<0.01〕;GFR水平显著减低〔(90.88±19.91)vs(109.10±32.43)ml·min-1·1.73m-2,P<0.01〕;GFR减低的MS患者血清内脂素水平明显高于GFR正常的MS患者〔(1.11±0.15)vs(1.03±0.16)ng/ml,P<0.05〕;直线相关分析GFR与血清内脂素水平呈显著负相关(r=-0.19,P<0.05);多元线性回归分析显示血清内脂素水平是GFR的独立
3、危险因素(β=-0.17,P<0.01)。结论血清内脂素水平与MS患者肾功能密切相关,可能是MS患者肾脏病变的重要参与因素。【关键词】 代谢综合征;内脏脂肪素;肾功能;肾小球滤过率Therelationshipofserumvisfatinandrenalfunctioninmetabolicsyndrome GUOLing,TANHongWei,WANGZhiHao,etal. KeyLaboratoryofCardiovascularRemodelingandFunctionResearch,ChineseMinistryofE
4、ducationandChineseMinistryofPublicHealth;DepartmentofCardiology,QiluHospitalofShandongUniversity,Ji′nan250012,Shandong,China 【Abstract】ObjectiveToinvestigatetheconcentrationofserumvisfatinandrenalfunction,andtheirrelationshipinmetabolicsyndrome(MS).MethodsAtotalof85patien
5、tswithMSand88controlswereincluded.Thepatientswerefurtherdividedintotwogroups:58caseswithGlomerularfiltrationrate(GFR)≥90ml·min-1·1.73m-2and27caseswithGFR<90·min-1·1.73m-2.Serumvisfatinconcentrationwasmeasuredbyenzymeimmunoassaymethod.ResultsComparedwithageandsexmatchedco
6、ntrols,theconcentrationsofserumvisfatinandcreatinineweresignificantlyelevatedinMSpatients〔(1.06±0.16)vs(0.98±0.25)ng/ml,P<0.05;(73.20±13.95)vs(63.93±13.78)μmol/L,P<0.01);theGFRwassignificantlydecreased〔(90.88±19.91)vs(109.10±32.43)ml·min-1·1.73m-2(P<0.01);andtheconcentrati
7、onofserumvisfatinwassignificantlyhigherinpatientswithGFR≥90ml·min-1·1.73m-2thanthatinpatientswithGFR<90ml·min-1·1.73m-2〔(1.11±0.15)vs(1.03±0.16)ng/ml,P<0.05).LinearcorrelationanalysisshowedthatGFRwassignificantlynegativelyrelatedtoserumvisfatin(r=-0.19,P<0.05).Multiplestep
8、wiseregressionanalysisrevealedthatelevatedconcentrationofserumvisfatinwasanindependentris
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