代谢综合征患者血清内脏脂肪素和肾功能变化的相关性研究

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1、代谢综合征患者血清内脏脂肪素和肾功能变化的相关性研究【摘要】 目的研究代谢综合征(MS)患者血清内脏脂肪素(Visfatin，简称内脂素)和肾功能的变化;并分析它们之间的内在联系。方法以85例MS患者和88例正常对照为研究对象，MS患者按GFR≥90ml·min-1·1.73m-2和GFR<90ml·min-1·1.73m-2分为两组，记录并检测临床和生化指标，采用酶联免疫法检测血清内脂素水平，MDRD公式法计算肾小球滤过率(GFR)。结果MS组和对照组年龄性别匹配。与对照组比较，MS组患者血清内脂素(对数值)和肌酐水平显著升

2、高〔(1.06±0.16)vs(0.98±0.25)ng/ml，P<0.05;(73.20±13.95)vs(63.93±13.78)μmol/L，P<0.01〕;GFR水平显著减低〔(90.88±19.91)vs(109.10±32.43)ml·min-1·1.73m-2，P<0.01〕;GFR减低的MS患者血清内脂素水平明显高于GFR正常的MS患者〔(1.11±0.15)vs(1.03±0.16)ng/ml,P<0.05〕;直线相关分析GFR与血清内脂素水平呈显著负相关(r=-0.19，P<0.05);多元线性回归分析显示

3、血清内脂素水平是GFR的独立危险因素(β=-0.17，P<0.01)。结论血清内脂素水平与MS患者肾功能密切相关，可能是MS患者肾脏病变的重要参与因素。【关键词】 代谢综合征;内脏脂肪素;肾功能;肾小球滤过率Therelationshipofserumvisfatinandrenalfunctioninmetabolicsyndrome　　GUOLing,TANHongWei,WANGZhiHao,etal.　　KeyLaboratoryofCardiovascularRemodelingandFunctionResear

4、ch,ChineseMinistryofEducationandChineseMinistryofPublicHealth;DepartmentofCardiology,QiluHospitalofShandongUniversity,Ji′nan250012,Shandong,China　　【Abstract】ObjectiveToinvestigatetheconcentrationofserumvisfatinandrenalfunction,andtheirrelationshipinmetabolicsyndrome

5、(MS).MethodsAtotalof85patientswithMSand88controlswereincluded.Thepatientswerefurtherdividedintotwogroups:58caseswithGlomerularfiltrationrate(GFR)≥90ml·min-1·1.73m-2and27caseswithGFR<90·min-1·1.73m-2.Serumvisfatinconcentrationwasmeasuredbyenzymeimmunoassaymethod.Resu

6、ltsComparedwithageandsexmatchedcontrols,theconcentrationsofserumvisfatinandcreatinineweresignificantlyelevatedinMSpatients〔(1.06±0.16)vs(0.98±0.25)ng/ml，P<0.05;(73.20±13.95)vs(63.93±13.78)μmol/L，P<0.01);theGFRwassignificantlydecreased〔(90.88±19.91)vs(109.10±32.43)

7、ml·min-1·1.73m-2(P<0.01);andtheconcentrationofserumvisfatinwassignificantlyhigherinpatientswithGFR≥90ml·min-1·1.73m-2thanthatinpatientswithGFR<90ml·min-1·1.73m-2〔(1.11±0.15)vs(1.03±0.16)ng/ml,P<0.05).LinearcorrelationanalysisshowedthatGFRwassignificantlynegativelyre

8、latedtoserumvisfatin(r=-0.19，P<0.05).Multiplestepwiseregressionanalysisrevealedthatelevatedconcentrationofserumvisfatinwasanindependentris