急性呼吸窘迫综合征机械通气进展黄茂急性呼吸窘迫综合征（a讲课稿.ppt

《急性呼吸窘迫综合征机械通气进展黄茂急性呼吸窘迫综合征（a讲课稿.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、急性呼吸窘迫综合征机械通气进展黄茂急性呼吸窘迫综合征（aResearchBackgroundAdiponectin,secretedbyadipocytes,hasbeenfoundrecentlytobeassociatedwithdiabetes,obesityandsomecardiovasculardiseases.Recentresearchsuggestedthatobstructivesleepapneasyndrome(OSAS)mightbeindependentlyassociatedwithhypoadi

2、ponectinemia,whichwaslinkedtosomecomplicationsofOSAS,suchashypertension,diabetes,etc.ObjectiveToinvestigatetheeffectofcontinuouspositiveairwaypressure(CPAP)treatmentonserumdiponectinelevelsinmaleOSASpatients.METHODSDiagnosisofOSASACompumedicpolysomnographerwasusedto

3、measureandrecordovernightpolysomnography(PSG)parameters.ThemininalcriteriafordiagnosisofSASisapneahypopneaindex(AHI)≥5.Theeventwasconsideredobstructivewhenchestandabdominalrespiratorymovementsexistedduringapnea.Subjects23adultmalepatientswithmoderateorsevereOSASAge

4、:41.4±11.8yrs(38~64yrs)BMI:24.7±2.12Theexclusioncriteria:type2diabetesorFBG>7.0mg/LBMI>28cardiovasculardiseasesotherchronicrespiratorydiseasesTestofserumadiponectinThreemlofvenousbloodwasdrawnat7:00amfollowing12hours’overnightfasting.Serumadiponectinlevelwasmeas

5、uredbyradioimmunoassay.TheagentkitforadiponectintestingwasprovidedbyLINCOResearchInc,USA.Theirbloodsampleswerecollectedandmeanarterialpressure(MAP,diastolicBp+1/3pulsepressure)wasmeasuredat6:00A.M.beforeCPAPtreatmentonday3,day7,day14ofCPAPtreatmentRESULTCompar

6、isonofserumadiponectinlevels,AHIandMAPbeforeandafterCPAPtreatment(x±s)(n=23)---------------------------------------------------AHIMAPadipolectin(mmHg)(mg/L)---------------------------------------------------beforeCPAP28.2±5.8101.2±8.13.95±0.21day3ofCPAP2.2±0.6**

7、98.8±7.64.01±0.27day7ofCPAP2.3±0.8**96.7±8.24.04±0.32day14ofCPAP1.9±0.6**90.5±6.7**4.46±0.46**------------------------------------------------------------------------*:P<0.05vsbeforeCPAPtreatment;**:P<0.01vsbeforeCPAPtreatmentMAP:meanarterialpressure=diastolicBp+1

8、/3pulsepressure＊＊P<0.01＊＊P<0.01DISCUSSIONDifferentserumadiponectinlevelsbasedondifferentAHIinOSASpatients＊P<0.05＊＊P<0.01＊P<0.05Mult