急性呼吸窘迫综合征机械通气进展黄茂急性呼吸窘迫综合征（a.pptx

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1、EffectofCPAPtreatmentonhypoadiponectinemiainmalepatientswithobstructivesleepapneasyndromeZhangXilong,YinKaishengThaFirstAffiliatedHospitalofNanjingMedicalUniversity,Nanjing,ChinaResearchBackgroundAdiponectin,secretedbyadipocytes,hasbeenfoundrecentlytobeassociatedwithdiabetes,obesi

2、tyandsomecardiovasculardiseases.Recentresearchsuggestedthatobstructivesleepapneasyndrome(OSAS)mightbeindependentlyassociatedwithhypoadiponectinemia,whichwaslinkedtosomecomplicationsofOSAS,suchashypertension,diabetes,etc.ObjectiveToinvestigatetheeffectofcontinuouspositiveairwaypressur

3、e(CPAP)treatmentonserumdiponectinelevelsinmaleOSASpatients.METHODSDiagnosisofOSASACompumedicpolysomnographerwasusedtomeasureandrecordovernightpolysomnography(PSG)parameters.ThemininalcriteriafordiagnosisofSASisapneahypopneaindex(AHI)≥5.Theeventwasconsideredobstructivewhenchestandabdo

4、minalrespiratorymovementsexistedduringapnea.Subjects23adultmalepatientswithmoderateorsevereOSASAge:41.4±11.8yrs(38~64yrs)BMI:24.7±2.12Theexclusioncriteria:type2diabetesorFBG>7.0mg/LBMI>28cardiovasculardiseasesotherchronicrespiratorydiseasesTestofserumadiponectinThreemlofvenousblood

5、wasdrawnat7:00amfollowing12hours’overnightfasting.Serumadiponectinlevelwasmeasuredbyradioimmunoassay.TheagentkitforadiponectintestingwasprovidedbyLINCOResearchInc,USA.Theirbloodsampleswerecollectedandmeanarterialpressure(MAP,diastolicBp+1/3pulsepressure)wasmeasuredat6:00A.M.before

6、CPAPtreatmentonday3,day7,day14ofCPAPtreatmentRESULTComparisonofserumadiponectinlevels,AHIandMAPbeforeandafterCPAPtreatment(x±s)(n=23)---------------------------------------------------AHIMAPadipolectin(mmHg)(mg/L)---------------------------------------------------beforeCPAP28.2±

7、5.8101.2±8.13.95±0.21day3ofCPAP2.2±0.6**98.8±7.64.01±0.27day7ofCPAP2.3±0.8**96.7±8.24.04±0.32day14ofCPAP1.9±0.6**90.5±6.7**4.46±0.46**------------------------------------------------------------------------*:P<0.05vsbeforeCPAPtreatment;**:P<0.01vsbeforeCPAPtreatmentMAP:meanarteri