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时间:2020-06-04
《进行性核上性麻痹患者中脑形态的MRI研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、临床放射学杂志2013年第32卷第11期·1555·中枢神经放射学进行性核上性麻痹患者中脑形态的MRI研究冯结映,黄飚,杨万群,王丽敏,张玉虎【摘要】目的探讨MRI中脑形态测量在诊断进行性核上性麻痹(PSP)的临床价值及其与帕金森病(PD)的鉴别诊断。方法经临床确诊的PSP患者l8例,分析其MRI的中脑形态影像学特征;并与年龄及性别相匹配的l8例PD患者和18名正常人对比。结果l8例PSP患者中14例可见“蜂鸟征”、10例见“牵牛花征”;PSP组中有17例表现为中脑平直或内凹,而PD组中仅有3例呈内凹型。PSP组的中脑/桥脑面积低于PD组和对照组;中脑/桥脑面
2、积之比<0.18提示PSP诊断。结论观察中脑萎缩对PSP具有较高的诊断价值,并能与PD相鉴别。【关键词】进行性核上性麻痹帕金森病磁共振成像MorphometryMRIStudyoftheMidbraininPatientswiUlProgressiveSupranuclearPalsyFENGJieying,HUANGBiao,YANGWanqun,eta1.SouthenMedicalUniversity,Guangdong510515,P.R.China【Abstract】ObjectiveToevaluatethevalueofmorphometryMR
3、Iofthemidbrainindiagnosisofprogressivesupranu-clearpalsy(PSP)anddiferentialdiagnosisbetweenPSPandParkinson,sdisease(PD).Methods18patientswithPSP.18agematchedpatientswithPDand18normalcontrolsubjectswereenrolled.Theimagingcharacteristicsofthemidbraininpatientswereanalyzed.ResultsHummi
4、ngbirdsignswasseenin14patientswithPSPandmorninggloryflow—ersignswereseenin10patients.Thepresencesofabnormalsuperiorprofileofthemidbrainweredemonstratedin17of18patientswithPSP,whileonly3patientswithconcavemidbraininPDgroupandnoneincontrolgroup.Theaverageratio(areaofmidbrain/areaofpon
5、s)ofthepatientswithPSP(0.17)wassignificantlysmallerthanthatofthepatientswithPD(O.23)andthatincontrolgroup(O.23).Themidbrain/ponsratio<0.18suggestedthediagnosisofPSP,andthediag-nosticsensitivityandspecificityweDg72.2%and88.9%.respectively.ConclusionTheevaluationofmidbrainatrophyisuse
6、fulindiagnosisofpatientswithPSP.andwhichcanhelptodifferentiatePSPfromPD.【Keywords】ProgressivesupranuclearpalsyParkinsondiseaseMagneticresonanceimaging本研究为国家自然科学基金资助项目(编号:81271560)作者单位:510515广州,南方医科大学(冯结映);510080广东省医学科学院,广东省人民医院放射科(黄飚、杨万群);神经内科(王丽敏、张玉虎);}通讯作者12LohlePN,VanMamemnH,Zwin
7、dermanKH,eta1.Onthepathogen-14沈纪芳,沈海林,丁乙.星形胶质细胞瘤术后残留或复发与放射esisofbraintumourcysts:avolume~cstudyoftumour,oedema性坏死的临床及MRI表现特点分析.苏州大学学报(医学版),andcyst.Neuroradiology,2000,42:6392002,22:56113SchoeneggerK,ObemdorferS,WaschitB,eta1.PeritumoraledemaonMR/atinitialdiagnosis:anindependentprogn
8、osticfactorforclio—
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