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1、[经典]血清胱抑素C评价慢性心衰患者早期肾功能损害的临床研究IIIIII血清胱抑素c评价慢性心衰患者早期肾功能损害的临床研究【摘要】目的探讨血清胱抑素C(Cystatin,Cys-C)对慢性心力衰竭(ChronicHeartFailure,CHF)患者早期肾功能损害的诊断价值。方法选择2009年2〜10月在我院急诊科住院的心脏病患者62例,并将其分为A、B两组。A组31例为无原发性肾脏病变的慢性心力衰竭患者,B组31例为无心力衰竭心脏病患者,另选32例健康志愿者作为健康对照组,设为C组。分别测定A、B、C三组Cys-C.血清肌酎(SCr)、尿素氮(Bun)及血清步。2-微球
2、蛋白(步。2-MG)水平,并进行统计分析。结果A组与B、C组相比,Bun>SCr>B。2-帽差异无统计学意义(P>0.05),而A组与B、C组相比,血Cys-C差异有统计学意义(P<0.01)o结论无原发性肾脏病变的心衰患者存在以肾小球滤过功能受损为特征的早期肾功能异常;心衰程度愈重,肾功能损伤愈明显,Cys-C检测可用于CHF患者早期肾脏损害诊断。【关键词】心力衰竭;肾功能实验;胱抑素C;肾小球滤过功能SermnCystatinC:TheSensitiveParameterinDiagnosingChronicHeartFailueWithEarlyRenalImpair
3、menWANGMin-min,ZHANGYan-zhen,ZHOUYan-ju,etal.WeifangMedicalCollege,Weifang261042,China[Abstract]ObjectiveTodiscussthechangesoftheSerumCystatinC(Cys~C)inpatientswithchronicheartfailueanddiagnosisearlyimpairmentofrenalfunction.MethodsTotally62patientswithheartdisease(Meettheinclusioncriteria
4、)fromFebruarytoOctober2009inemergencydepartmentofourhospitalwereselectedtoassignintoA,Bgroups.GroupAhas31casesofprimarykidneydisease-freepatientswithchronicheartfailureandgroupBhas31patientsfreeofheartfailurepatientswithheartdisease,thegroupCis32casesofotheroptionsasahealthycontrolgroupofh
5、ealthyvolunteers.SerumCystatinC,bloodcreatinine,ureanitrogenand3^2-MGweremeasuredin31patientswithCHF,31patientswithcardiovasculardiseasesbutcompensatedheartfunctionand32normalvolunteers.ResultsThegroupABun,SCr,P-MGascomparedwithgroupBandCwasnosignificantdifference(P>0.05).ThegroupACys~Casc
6、omparedwithgroupBandCwasstatisticallysignificant(P<0.01).ConclusionThereisearlyabnormalityofrenalfunctioninCHFpatientswithoutprimaryrenaldisorderandtheabnormalitywasfeaturedbyimpairedglomorularfiltrationfunction.Themoreseveretheheartfailure,themoresignificanttherenalfunctionimpairment.Cys-
7、Cwasamarkerofearlyimpairmentofrenalfunctioninchronicheartfailure.[Keywords]Heartfailure;Kidneyfunctiontests;CystatinC;Glomerularfiltrationfunction随着社会人口老龄化和心血管病患者生存口寸间的延长,CHF的患病率逐渐升高,而CHF患者出现的进行性肾功能损害,并导致肾功能不全(即心肾综合征)的问题,逐渐引起人们的重视[1,2],如何在评估心力衰竭患者预后、制定治疗措施时是一个