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时间:2020-04-23
《舒芬太尼复合小剂量纳美芬对术后静脉自控镇痛效能的作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、262中国中西医结合外科杂志2014年6月第20卷第3期舒芬太尼复合小剂量纳美芬对术后静脉自控镇痛效能的作用周汾,李肇端,余剑波摘要目的:观察舒芬太尼复合小剂量纳美芬用于术后静脉自控镇痛效果和对胃肠动力变化的影响。方法:选择全麻术后静脉白控镇痛患者58例,按照随机数字表法随机分为2组,对照组(舒芬太尼组)镇痛泵配方为舒芬太尼2~gCkg、氟哌利多2.5mg稀释至100mL,纳美芬组(纳美芬一舒芬太尼组)在对照组基础上加纳美芬O.5~g/kg。结果:与对照组相比,纳美芬组恶心呕吐发生率明显降低,首次
2、排气时间明显缩短3、gesiaandGastrointestinalMotilityinPatientsthPCIAZHOUFen,LIZhao-duan,YUJian-poDepartmentofAnesthesia,TianjinNankaiHospital,Tianjin(3oowo),ChinaToobservetheeffectsofsufentanilcombinedwithultra—smalldosesofnalmefeneonpostoperativeintravenousanalgesicefec4、tsandgastrointestinalmotilitychanges.MethodsFiflyeightpa-tientswithintravenouscontrolledanalgesia(PCIA)aftergeneralanesthesiawererandomlydividedintocontrolgroupandnalmefenegroupaccordingtorandomnumerictable,andeachgrouphad29patients.Analgesiapumpformu5、lationsforthecontrolgroup(sufentanilgroup)wasinfusedwithsufentanil50I~g+droperidol2mg+salinedilutedto100mL.nalmefenegroup(nalmefene-sufentanilgroup)usedsufentanilplusnalmefene0.5Ixg/kgonthebasisofthecontrolgroup.VASpainscoreandadverseevents(nausea,vom6、iting,itchingandrespiratoryde—pression),exhausttimeforthefirsttime24hoursafteroperation,andplasmamotilinlevelweredetectedduringpostoperative48h.ResultsBothgroupsmadegoodanalgesiceffect.butnalmefenegroupwassignificantlybet—terthanthecontrolgroup.Compar7、edwithcontrolgroup,theincidenceofnauseaandvomitinginthenalmefenegroup,wassignificantlyreduced,thetimeoffirstexhaustionwassignificantlyshortenedwithstatisticallysignifi-cantdiference<0.05).Comparedwithpreoperation,themotilinlevelsinbothgroupswereelevat8、ed;com—paredwithcontrolgroup,thesecretionpeakinnalmefenegroupwassignificantlydelayed.ConclusionLowdosenalmefenemayenhancetheanalgesiceffect,reducetheincidenceofpostoperativenauseaandvomitingcausedbysufentanil,aswellaspromotetherecoveryofbowelm
3、gesiaandGastrointestinalMotilityinPatientsthPCIAZHOUFen,LIZhao-duan,YUJian-poDepartmentofAnesthesia,TianjinNankaiHospital,Tianjin(3oowo),ChinaToobservetheeffectsofsufentanilcombinedwithultra—smalldosesofnalmefeneonpostoperativeintravenousanalgesicefec
4、tsandgastrointestinalmotilitychanges.MethodsFiflyeightpa-tientswithintravenouscontrolledanalgesia(PCIA)aftergeneralanesthesiawererandomlydividedintocontrolgroupandnalmefenegroupaccordingtorandomnumerictable,andeachgrouphad29patients.Analgesiapumpformu
5、lationsforthecontrolgroup(sufentanilgroup)wasinfusedwithsufentanil50I~g+droperidol2mg+salinedilutedto100mL.nalmefenegroup(nalmefene-sufentanilgroup)usedsufentanilplusnalmefene0.5Ixg/kgonthebasisofthecontrolgroup.VASpainscoreandadverseevents(nausea,vom
6、iting,itchingandrespiratoryde—pression),exhausttimeforthefirsttime24hoursafteroperation,andplasmamotilinlevelweredetectedduringpostoperative48h.ResultsBothgroupsmadegoodanalgesiceffect.butnalmefenegroupwassignificantlybet—terthanthecontrolgroup.Compar
7、edwithcontrolgroup,theincidenceofnauseaandvomitinginthenalmefenegroup,wassignificantlyreduced,thetimeoffirstexhaustionwassignificantlyshortenedwithstatisticallysignifi-cantdiference<0.05).Comparedwithpreoperation,themotilinlevelsinbothgroupswereelevat
8、ed;com—paredwithcontrolgroup,thesecretionpeakinnalmefenegroupwassignificantlydelayed.ConclusionLowdosenalmefenemayenhancetheanalgesiceffect,reducetheincidenceofpostoperativenauseaandvomitingcausedbysufentanil,aswellaspromotetherecoveryofbowelm
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