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1、ArchVirol(1987)96:29-38ArchivesofVirology©bySpringer-Verlag1987Antigenicandbiologicaldiversityoffelinecoronaviruses:felineinfectiousperitonitisandfelineenteritisvirus*G.T.Tupper1,J.F.Everrnann3,R.(LRussell2,andM.E.ThoulessL2DepartmentofPathobiology,andDiv
2、isionofAnimalMedicine,UniversityofWashington,Seattle,andDepartmentofVeterinaryClinicalMedicineandSurgery,CollegeofVeterinaryMedicine,WashingtonStateUniversity,Pullman,Washington,U.S.A.AcceptedMarch21,1987SummaryAntigenicallyrelatedfelinecoronavirusescause
3、twodistinctdiseasemanifestationsininfectedcats.Thediseasesarefelineinfectiousperitonitis(FIP),inwhichthevirusiswidelydisseminated,andfelineentericcorona-virus(FECV),amilddiseaseinwhichthevirusisusuallylimitedtothevilli.Thesetwoviruseswerefoundtodifferinth
4、eirgrowthincellculture.FIPVgrowstohighertiter,formslargerplaquesandswitchesoffhostcellproteinsynthesismoreeffectivelythanFECV.Crossneutralizationstudiesshowedantigenicdifferencesbetweenthestrains.Therealsoappearedtobeadiffer-enceinthenucleoproteinmolecula
5、rweightofthevirusescausingthesetwodifferentdiseasesyndromes.IntroductionAntigenicallyrelatedi~linecoronaviruses(FCV)causetwodifferentdiseasemanifestationsincats(12,14,15,17).Thefirstisknownasfelineinfectiousperitonitis(FIP),andischaracterizedbyperitonitis
6、and/orpleuritiswithoccasionalcentralnervoussystemandocularinvolvement(7).Theinflammatoryinfiltrateconsistsoflymphoeytes,plasmacells,andmacrophagesresultingineithernonsuppurativeoragranulomatousinflam-marion.Theseconddiseaseiscausedbyfelineentericeoronavir
7、us(FECV)andisasubclinicalormildentericinfectioninwhich,lesionsarelocatedintheupperthirdofthevilliofthesmallintestine(16).Althoughthesevirusesareassociatedwithverydifferentdiseasesyndromes,evidencehas*ThisworkwassupportedbygrantNIH/RR01203-07.30G.T.T~ppere
8、tal.:suggestedthatthevirusesareantigenicMlyandbiologieMlysimilar(12).Itwasreportedthatbothvirusstrainsproducerelativelylargeplaquesincellcultureandgrewtofairlyhightiters(1).Inaddition,theirpolypeptidesappearedtobeth
