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1、ArchivesofVirologyArchivesofVirology58,45~53(1978)©bySpringer-Verlag1978AntiflenieRelationshipoftheFelineInfectiousPeritonitisVirustoCoronavirusesofOtherSpecies*ByN.C.PEDERSEI~I,J.WARD2,andW.L.MEIVGELI:NG3iDepartmentofMedicine,SchoolofVeterinaryMedicine,University
2、ofCalifornia,Davis,California,U.S.A.2:NationalInstituteofHealth,Bethesda,Maryland,U.S.A.:NationalAnimalDiseaseCenter,Ames,Iowa,U.S.A.With2FiguresAcceptedFebruary23,1978SummaryUtilizingthedirectandindirectfluorescentantibodyprocedure,theantigenicrelationshipofthefe
3、lineinfectiousperitonitisvirus(FIPV)to7otherhumanandanimalcoronaviruseswasstudied.FIPVwasfoundtobecloselyrelatedtotransmissiblegastroenteritisvirus(TGEV)ofswine.TransmissiblegastroenteritisvirusandFIPVwereinturnantigenicallyrelatedtohumaneoronavirus229E(I-ICV-229E
4、)andcaninecoronavirus(CCV).Aninterestingfindinginthestudywasthatthe8eoronavirusesselectedforthisstudyfellintooneoftwoanti-genicallydistinctgroups.Virusesineachgroupwereantigenieallyrelatedtoeachothertovaryingdegrees,butwereantigenicallyunrelatedtocoronavirusesofth
5、esecondgroup.Thefirstantigenicallyrelatedgroupwascomprisedofmousehepa-titisvirus,type3(MI-IV-3),hemeagglutinatingencephalomyelitisvirus67N(HEV-67N)ofswine,calfdiarrheacoronavirus(CDCV),andhumancoronavirusOC43(HCV-OC43).Thesecondantigenicallyrelatedgroupwascomprise
6、dofFIPV,TGEV,HCV-229EandCCV.IntroduetionThefamilyCoronaviridaeisarecentlycharacterizedgroupofanimalandhumanviruses(23).Coronavirusesare60to220nmindiameter,haveabuoyantdensityinsucroseof1.16to1.23g/cm3,aresensitivetolipidsolvents,containalargesinglestrandofribonucl
7、eicacid,haveregularlyspacedsurfaceprojections*ThisresearchwassupportedbygrantsfromtheWinnFoundationoftheCatFanciersofAmericaandtheS.O.C.K.Organization,Lafayette,California.0304-S608/7S/OO5S/O045/$01.8046N.C.PEDERSEN,J.WAI~D,andW.L.MESrG~LL~G:thatare12to24nminlengt
8、h,andbudfromprofilesofendoplasmicreticulumintocytoplasmicvesiclesintheinfectedcells(23).Coronavirusescausebronchitisinchickens(5),humans(7,10)andrats(14
