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1、液基薄层细胞学检测在宫颈上皮内瘤变和宫颈癌诊断中的应用价值分析【摘要】日的:探讨液基薄层细胞学技术(TCT)在诊断宫颈上皮内瘤变及宫颈癌中的应用价值。方法:选取2012年6月至2013年12月期间在我院接受宫颈病变筛查的681例患者作为研究对象,行TCT检查及阴道镜下宫颈活检,探讨年龄与发病率的关系,同时对比研究TCT细胞学与组织学诊断结果。结果:TCT阳性率多见于36~45岁年龄段;TCT细胞学诊断ASC-H60例,ASC-US222例,LSTL89例,HSIC14例,SCC5例,AGC2例;组织学诊断CINI178例,CINII114例,CINIII33例,SCC13例,以组织学诊断为金标
2、准,ASC-II符合率为9167%(55/60),ASC-US为3423%(76/222),LSIL为8764%(78/89),HSIC为9286%(13/14),SCC为100%(2/2)0结论:液基薄层细胞学技术(TCT)具有较高的阳性检出率,是筛查宫颈上皮病变的重耍手段,有助于宫颈上皮内瘤变和宫颈癌的早期诊断及治疗。【关键词】液基薄层细胞学技术;宫颈上皮内瘤变;宫颈癌;诊断价值TheapplicationofTCTinthediagnosisofcervicalepitheliallesionsandcervicalcancerHANYixu,ZENGXin.DepartmentofOb
3、stetricsandGynecology,IlairmnNongkenGeneralHospital,Ilaikou570203,China[Abstract]Objectives:ToinvestigatetheapplicationvalueofTCTinthediagnosisofcervicalepitheliallesionsandcervicalcancer.Methods:681patientsthatreceivedcervicallesionsscreeninginourdepartmentfromJune2012toDecember2013wereselectedandw
4、eretestedbyTCTandcolposcopycervicalbiopsy.Therelationshipbetweenageandincideneeratewasexplored,andresuItsofTCTcytologicalandhistologicaldiagnosiswerecompared.Results:ThepositiverateofTCTwashigherinpatientsof36~45yearsold.TherewereASC-H(60cases),ASC-US(222cases),LSIL(89cases),HSIC(14cases),SCC(5cases
5、)andAGC(2cases)diagnosedbyTCTcytology,and178casesofCINI,114casesofCINII,33casesofCINIIIand13casesofSCCdiagnosedbyTCT.Choosinghistologicaldiagnosisasthegoldstandard,thecoincidencerateofASC-H,ASC-US,LSTL,HSTCandSCCwere91.67%(55/60),34.23%(76/222),87.64%(78/89),92.86%(13/14)and100%(2/2)respectively.Con
6、clusion:Withahighpositiverate,TCTisanimportantscreeningmeansforcervicalintraepitheliallesions,whichisconducivetoearlydiagnosisandtreatmentofcervicalintraepithelialneoplasiaandcervicalcarcinoma・[Keywords]TCT;Cervicalintraepithelialneoplasia;Cervicalcancer;Diagnosticvalue【中图分类号】R167【文献标志码】A宫颈癌属于女性最常见的
7、恶性肿瘤,在我国发病率及死亡率约占世界的35%,且每年新发宫颈癌病例超过11万,发病呈年轻化趋势[1,2]0宫颈上皮内瘤变(cervicalintraepithelialneoplasia,CTN)是与宫颈癌相关的癌前病变的统称,可分为宫颈不典型增生及宫颈原位癌,是宫颈癌进展过程中的必经阶段[3,4]。有效的筛查手段是早期诊断及治疗宫颈上皮内瘤变的关键。宫颈上皮病变发展到宫颈癌需经历较长可逆转阶段