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页数:19页
时间:2019-10-17
《CAC GL 03-1989GUIDELINES FOR SIMPLE EVALUATION OF FOOD ADDITIVE INTAKE》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、1CAC/GL3Page1of19GUIDELINESFORSIMPLEEVALUATIONOFFOODADDITIVEINTAKECAC/GL03-1989________CONTENTS1.INTRODUCTION2.BACKGROUND2.1AcceptableDailyIntake(ADI)2.2TheoreticalMaximumDailyIntake(TMDI)2.3EstimatedDailyIntake(EDI)3.ACCEPTABLEDAILYINTAKEANDINTAKEESTIMA
2、TES4.DATAAVAILABLE4.1Foodconsumptionandregulationofuseoffoodadditives4.2Approachesfordeterminingfoodconsumptiondata5.SIMPLEAPPROACHFORTHEEVALUATIONOFFOODADDITIVEINTAKE5.1Additivesforwhichanevaluationofintakewouldhavetobedone5.2Proposedmethodforasimpleeva
3、luationoftheintakeofanadditive6.SUMMARYANNEXI-ExampleofcalculationforbenzoicacidANNEXII-Exampleofcalculationforsweeteners2CAC/GL3Page2of191.INTRODUCTIONThefirststepinthepermitteduseoffoodadditivesistheexaminationoftoxicologicalstudiesbytheJointExpertComm
4、itteeonFoodAdditives(JECFA),theestablishmentofanAcceptableDailyIntake(ADI),andtheelaborationofidentityandpuritycriteria.Inthesecondstep,proposalsforthepermitteduseofanadditiveindifferentfoodstuffsaremadebytheresponsiblegovernmentalagenciesorbytheCodexcom
5、moditycommitteestotheCodexCommitteeonFoodAdditivesandContaminants(CCFAC).TheendorsementoftheproposeduseinafoodstuffisdoneinaccordancewiththeGeneralPrinciplesfortheUseofFoodAdditives(CodexAlimentariusCommissionProceduralmanual,6thEd.p.144,1986)whichstates
6、that"Approvalortemporaryapprovalfortheinclusionofafoodadditiveinanadvisorylistorinafoodstandardshould:...(iii)asfaraspossibletakeintoaccountanyAcceptableDailyIntake,orequivalentassessment,establishedforthefoodadditive,andtheprobabledailyintakeofitfromall
7、sources.Wherethefoodadditiveistobeusedinfoodseatenbyspecialgroupsofconsumers,accountshouldbetakenoftheprobabledailyintakeofthefoodadditivebyconsumesinthosegroups."Informationregardingtheprobabledailyintakeisthereforeneeded,especiallyinthecaseoffoodadditi
8、veswithlowADI,highlevelsofanadditiveinafoodofhighconsumptionand/ortheuseofadditivesinfoodeatenbyspecialpopulationgroups.Differentapproachesexistasregardstheestimationoftheprobabledailyintake,someofthesebeingveryexpensivean
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