改变非小细胞肺癌适形放疗纵隔照射靶体积的对照分析

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1、patients)beforeRRT，thesepatientshadn’treceivedPNIofmediastinallymphnodedrainagewherehadn’tmetastasisbelievedbyCTcombinedwithPET．PatientswithoutPET(non—PETpatients)hadreceivedPNIaccordingtoconventionalmethod．ThedifferenceofCTVbetweentwogroups、,VaS133．31士34．26cm3．Allpa

2、tientsintwogroupsweretreatedwiththeSOATIemethod．Peripherallesionsinlungweretreatedwithlowfmctionatedradiotherapy(LFRT)，以8Gyineveryonefraction，3fractionsinaweek，andatotaldoseof56～60Gyweredeliveredin7～10fractionswithin2～3weeks．LesionsinhilaandmediastinHalweretreatedwit

3、hAFRT,3Gyineveryonefraction，5fractionsinaweek，apreventivedoseof42～45Gyweredeliveredin14～15fractionswithin3weeks，andaradicalradiationdoseof60～63Gyweregivenin20-21fractionswithin4~5weeks．Twoyearssurvivalrate．10calcontroloflymphnodedrainageandirradiationinjuryoflungando

4、esophagusbetweenthetwogroupshadbeencompared．Statisticalanalysis：AlldatawereanalysedbythesoftwarepackagesofSPSS10．OResults：Thefirstpart：Twoyearssurvivalratesofpatientsintwopost—operationradiotherapygroupswere55．2％and62．5％respectivelyrP=0．59)．Thelocalregionalrelapserat

5、esandtherecnrrenceoutofCTVwere13．8％．3．4％forgroupAand16．7％．8．3％forgroupBrespectively(P=-iandP-=0．571)．TherewerenodecreaseofthelocalcontrolingroupBbythereductionofCTV．Theradiationpneumoniaandlungfibrosisrateswere6．9％．62．1％forgroupAand0．58．3％forgroupBrespectively(e=-0．4

6、59andP=0．782)．Theradiationoesophagitisandoesophagusstricturerateswere37．9％．6．9％forgroupAand12．5％．4．2％forgroupBrespectively(P=-0．039andP=-1)．Theincidenceofradiationoesc。phagitisingroupBweredecreasedsignificantly．Thesecondpart：TwoyearssurvivalrateofRRTwas53．1％forPETpat

7、ientsand43，2％fornon-PETpatientsrespectivelyrP=0．357)．Thedistantmetastasisratewas25．0％forPETpatientsand52．3％fornon—PETpatients5respectivelyfP=0．0174)．Thelocalregionalrelapseratesofthehilaandmediastinunawere21．9％forPETpatientsand25．0％fornon—PETpatientsrespectively(e=-0

8、．752)．TherecurrenceoutofCTVwere6．3％forPETpatientsand4．5％fornon—PETpatientsrP=O．831)．Theradiationoesophagisandoesophagusstricturerat