不同剂量尿激酶溶栓超早期治疗对急性脑梗死患者临床疗效与影响因素分析

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1、万方数据天津医科大学硕士学位论文0BJECTIVEAbstractWithacuteinfarctiongraduallyincreaseddiabetesriskfactors，hypertension，highcholesterolincidence，ACIincidenceincreases．ACIisduetoatherosclerosisorothercausesbrainarterystenosis，occlusion，andcerebralarterialsupplyareaisnottimel

2、yformationofcollateralcirculation，resultingininsufficientbloodsupplytothelocalbraintissue，nervecellsinthebraintissueofoxygenduetonoadequatesupply，causingcellularenergymetabolism，thelastpartofischemicneuronalorglialcelldamageoccurs，apoptosisornecrosis，clinic

3、almanifestationsperformanceiscentralnervoussystemdamage，suchascentralnervoussystemsystemicparalysis．ThestudyfoundtheACIultra-earlythrombolyticrestorebloodsupplytotheischemicareamayreduceischemicpenumbraischemicneuronaldamage，restorethefunctionofnervecells．B

4、utforclinicalusagefortheUKthereisnoobviousrequirement，andsomeresearchersbelievethatlargedosescanleadtoincreasedbleedingcomplicationsUK，itadvocatestheuseofsmalldosesofUK，someresearchersbelievethatsmalldosesofUKandnottimelythrombolysis，thenthroughbloodvessels

5、，delaysinrescuenervecells，brainhemorrhageandthrombolysiswithUKusagewithoutdirectcontact，SOtheUKadvocatetheuseofhigh—dosetherapy．Inthisstudy,ACIpatientsforthestudy,toexploretheefficacyofdifferentdosesofUKandcomplications，andtostudythefactorsUKthrombolyticeff

6、icacyandcomplicationsoftherapyforclinicaluseUKACI，ACIimproveprognosistheoreticalreference．METHODChoosefromDecember2012toDecember2013inOurhospital109casesofpatientsdiagnosedwithacutecerebralinfarction，68casesweremale，aged42—73years，meanage(59．39士14．82)years，

7、female41cases，aged42-71years，meanageVl万方数据天津医科大学硕士学位论文(58．424-14．09)yearsofage．ThepatientsweredividedaccordingtotherapeuticdosesUK25×104Ugroup，UK45×104Ugroup，UK75×104Ugroup，UK150×104Ugroupandthecontrolgroup，whichisthebasisforthecontrolgroupofpatientstreated

8、，20cases，UK25×104Ugroup，22cases，UK45×104Ugroup，22cases，22casesofUK75×104Ugroup，UK150×104Ugroup，23cases．Observedbeforeandaftertreatmentofthefollowingindicatorsafterthrombolyticrecanalizationcases，motorf