复方丹参滴丸对缺血性脑血管病患者血浆溶血磷

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1、复方丹参滴丸对缺血性脑血管病患者血浆溶血磷摘要：目的：探讨疑似脑供血不足、短暂性脑缺血发作(TIA)、进展性脑梗死及脑梗死早期的患者血浆溶血磷脂酸(LPA)水平的变化及复方丹参滴丸对血浆LPA的影响。方法：采用有机溶剂抽提、分离溶血磷脂酸,以定磷方法测定疑似脑供血不足及缺血性脑血管病患者98例血浆LPA的水平,并与正常对照组比较。对疑似脑供血不足组和TIA组的36例患者,每日给复方丹参滴丸,1个月后复查LPA并与服药前比较。结果：疑似脑供血不足、TIA、进展性脑梗死及脑梗死早期患者的血浆LPA水平分别为(3.95±0.78)μmol/L、(5.16&pl

2、usmn;0.88)μmol/L、(4.31±1.32)μmol/L、(2.98±1.04)μmol/L,显著高于正常对照组(2.02±0.71)μmol/L(均P<0.05)。经复方丹参滴丸干预者1个月后复查血浆LPA为(1.96±0.91)μmol/L,与服药前(4.31±1.21)μmol/L比较,差异有极显著性(均P<0.01)。结论：血浆LPA水平的测定可能有助于对缺血性脑血管病的早期诊断;口服复方丹参滴丸可有效降低缺血性脑血管病患者血浆LPA水平

3、。　　关键词：复方丹参滴丸；缺血性脑血管病；溶血磷脂　　TheInfluenceofplexDanshenDrippingPillsAgainstPlasmicLysophosphatidicacidofIschemicCerebrovascularDiseasePatients　　Abstract：Objective：Inordertoinvestigatethechangelevelofplasmiclysophosphatidicacid(LPA)tothedoubtfulbraininsufficiencyofblood,transientischemicattac

4、k(TIA),progressivecerebralinfarctionandpristinecerebralinfarctionpatientsandtheeffectofplexdanshendrippingpillsinplasmiclysophosphatidicacid．Ｍethod：DetermineplasmicLPAlevelto98patientsofdoubtfulbraininsufficiencyofblood，TIA，progressivecerebralinfarctionandpristincerebralinfarctionethodsofd

5、issolventextraction,abstractionoflysophosphatidicacid,fixationofphosphours,giveplexdanshendrippingpillsto36patientsofdoubtfulbraininsufficiencyofbloodandcontrasttheresultsoftheexperimentalgroupsandcontrolgroups．Result：PlasmicLPAlevelinthepatientsofdoubtfulbraininsufficiencyofblood，TIA，prog

6、ressivecerebralinfarctionandpristinecerebralinfarctionis(3.95±0.78)μmol/L,(5.16±0.88)μmol/L,(4.31±1.32)μmol/L,(2.98±1.04)μmol/L,respectivelysignificantdifferencen;0.71)μmol/L(P<0.05)andparetheplasmicLPAlevelofinterfereceinplexdanshendrippingpil

7、lsforamonth(1.96±0.91)μmol/Ln;1.21)μmol/L,theresulthassiganificantdifference(P<0.01).Conclusion：DeterminationofplasmicLPAmaybehelpfultoearlydiagnosistoischemiccerebrovasculardisease,andplexdanshendrippingpillsorallycanloicLPA．　　Keyiccerebrovasc