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ID:14370870
大小:3.42 MB
页数:19页
时间:2018-07-28
《细胞骨架连接分子ezrin及cdv对胃癌生长和转移影响》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、结论1、胃癌组织中存在Ezrin及CD44v6的表达,二者之间表达呈正相关。2、Ezrin及CD44v6在胃癌组织中的表达明显高于对照组。3、胃癌组织中Ezrin及CD44v6的表达与组织分型、淋巴结转移、Borrmann分型相关。Ezrin及CD44v6与胃癌的侵袭和转移相关。与患者年龄、性别、肿瘤大小、浸润深度无明显联系。关键词胃肿瘤;Ezrin;CD44v6;侵袭和转移;免疫组化2二口己◆・英文论著摘要・CytoskeletonlinkermoleculesEzrinandCD44v6onthegrowt
2、handmetastasisofgastricobjectivecancerEzrinandCD44v6detectedinnormalgastricmucosa,gastriccancerandtoanalyzeitsexpressionindifferentcases,thelinksanddifferences,anddiscussitsinvasionandmetastasisofgastriccanceranditssignificance.MethodsCollectionofChin
3、aMedicalUniversityHospitalinOctober2009MukdeninMatch・2010surgicalresectionspecimensof84casesofgastriccancerpatientsasagroup(theedgeofeachofthetumorspecimensthan5cmawayfromthenormalgastricmucosaascontrols).CasesdetectedbySPgroupandthecontrolgroup,thee
4、xpressionofEzrinandCD44v6.Andtheresultswereanalyzed.ResultsThepositiverateofEzrinproteiningastriccancer(84.5%);weresignificantlyhigherthanthatinnormalgastricmucosa(61.9%1respectivelyP<O.05Ezrinproteinexpressioninlymphnodemetastasisrate(88%),caseandcontrol
5、groupsweresignificantlydifferent,P<0.05.Inthecaseofthetissuetypinginwell—differentiatedgastriccancerEzrinproteinexpressionrate(93.8%);poorlydifferentiatedgastricEzrinproteinexpressionrate(71.4%);twotypeP<0.05,thereatedifferences.Inthepatientgroup埘mlymphno
6、demetastasisandwithoutlymphnodemetastasis,thepositiverateofP<0.05.CD44v6proteinexpressioninthecellmembrane,gastriccancer,thepositiveexpressionrate(75%);CD44v6proteinexpressioninnormalgastricmucosarate(51.2%);CD44V6proteinexpressioninlymphnodemetastasi
7、srate(78%),caseandcontrolgroupsweresignificantlydifferent.P<O.05.Poorlydifferentiatedgastriccancer);twotypeP<0.05,thereateConclusionI.C.vdstriccancertissuesintheexpressionofEzrinandCD44v6,wasapositivecorrelationbetweenthetwo.2.EzrinandCD44v6expressio
8、ningastriccancerwassignificantlyhigher.3.CD44v6ingastriccancerandtheexpressionofEzrinandhistologicaltype,lymphnodemetastasis,Borrmanntyperelated.EzrinandCD44v6ingastriccancerinvasion
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