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1、AspirinforthepreventionandtreatmentofcardiovascularandcerebrovasculardiseasesstatusquoAbstract:Aspirinisaclassicnon-steroidalantipyreticanalgesics,initiallyasanantipyreticanalgesicsusetodayiswidelyusedclinicallytoreducetheincidenceofcardiovascularandcerebr
2、ovasculardiseases(primarypreventionandtoimprovediseaseprognosisandrecurrence(secondaryprevention,aswellascardiovascularandcerebrovasculardiseases,acutephasetreatmentoffirst-linedrugs,thisarticleonaspirinforcardiovasculardiseasepreventionandcontrolofthestat
3、usquoanddoareview.Keywords:aspirin,cardiovascularandcerebrovasculardisease,preventionAspirin,alsoknownasacetylsalicylicacid,initiallyasanantipyreticanalgesics,alongwiththedevelopmentofmedicineaswellaslong-termclinicalpracticehasproveditspharmacologicaleffe
4、ctsadditionantipyreticanalgesicanti-rheumatic,alsohassignificantanti-plateletcohesionroleandplaysanimportantroleinthepreventionof12cardiovasculardisease.modernclinicalaspirinasaneffectiveanti-plateletaggregationdrugsarewidelyusedinthepreventionofcardiovasc
5、ularandcerebrovasculardiseases,manyyearsofclinicaltrialshaveprovidedstrongevidence-basedmedicineevidencethataspirincanmakehigh-riskpatientswithmyocardialinfarction,strokeandotherthromboticvasculareventsandnon-fatalstrokewerereducedby1/4,1/3reductioninnon-f
6、atalmyocardialinfarction,andvasculardeathisreducedby1/6[1,2].mechanismofaspirin’sroleinpreventionandtreatmentofcardiovasculardiseasestatusquodoareview.Amechanismofthrombosisisthebasisoftheincidenceofcardiovascularandcerebrovascularevents,myocardialinfarcti
7、on,stroke,angina,cancauseplateletaggregationcorestepsthrombosis,whileaspirinhasirreversibleinhibitionofplateletaggregation,therebypreventingplateletaggregationthrombosis,andthusplayaroleinthepreventionofmyocardialinfarction,stroke,andothercardiovascularand
8、cerebrovascularevents.thromboxaneA2(ofTXA2activatedplateletspromoteplateletaggregationthrombosissubstances,whileaspirin12withplateletcyclooxygenasecombined,resultinginTAX2reducethesynthesistoproduceanti-plate
