hs-crp与cta冠状动脉造影不同类型斑块及狭窄程度之间的相关性研究

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1、hs-CRP与CTA冠状动脉造影不同类型斑块及狭窄程度之间的相关性研宄代小兵何川东钟唐力何瑜周莹孙凤刘启榆通讯作者绵阳市屮心医院放射科四川绵阳621000目的：探讨hs-CRP与冠状动脉CTA不同类型斑块及狭窄程度之间的相关性。方法：回顾性分析352名无症状的临床诊断冠心病患者的冠状动脉CTA资料。分别采用单因素方差分析和多因素logistic回归分析不同斑块类型间hs-CRP浓度差异及hs-CRP与冠状动脉斑块及血管狭窄程度之间的关系。结果：非钙化型组(NCAP)和混合型斑块组(MCAP)hs-CRP浓度与钙化斑块组(CAP)hs-CRP之间差异有统计学

2、意义(P<0.05),而NCAP组和MCAP组之间hs-CRP浓度差异无统计学意义(P=0.384)；纳入传统心血管疾病危险因素后行多因素logistic回归分析显示hs-CRP浓度是NCAP形成及冠状动脉显著狭窄的独立预测因素(oddsratio=1.70,P=0.025;oddsratio=1.76,P=0.020)。结论:hs-CRP浓度与无症状冠心病患者CTA冠状动脉造影屮NCAP形成及血管显著狭窄相关，因此hs-CRP浓度对冠心病患者的临床诊断及危险程度评估有重要意义。【关键词】超敏C反应蛋白；冠状动脉疾病；CT血管成像；危险因素R541A

3、1674-8999(2015)9-0586-02【Abstract】Objective:!"。determinewhetherhs-CRPisrelatedtothepresenceofsubclinicalcoronaryplaqueandstenosis.Methods:352subjectswhounderwentCTAfortheassessmentofcoronaryarterydisease(CAD)werestudied.Allthesubjectsenrolledhadnoclinicalcardiovasculardiseasesympt

4、oms.Thepresenceofplaquetype(calcified,mixedcalcified,ornoncalcified),stenosisdegree,andhs-CRPlevelswereevaluated.Analysisofvariance(ANOVA)wasusedtocomparethehs-CRPlevelsofthreegroups(calcified,mixedcalcified,ornoncalcifiedplaque).Multivariatelogisticregressionanalysiswasusedtoeval

5、uatetheassociationofC-reactiveproteinwithcoronaryplaquesubtypeandstenosis.Results:Thelevelsofhs-CRPinthenoncalcifiedandmixedplaquegroupweresignificantlyhigherthanthoseincalcifiedplaquegroup(P<0.05),buttherewasnostatisticaldifferencebetweenthenoncalcifiedandmixedplaquegroup(P=0.

6、384).Multivariateadjustmentfortraditionalcardiovascularriskfactorsthroughlogisticregressionanalysisshowedthaths-CRPlevelwasanindependentpredictorforthepresenceofnoncalcifiedplaque(oddsratio=1.70,P=0.025)andsignificant(50%andhigher)coronarystenosis(oddsratio=1.76,P=0.020).Conclusio

7、n:Ourstudyshowshs-CRPisindependentlyassociatedwithboththeseverityandnoncalcifiedplaquedetectedbyCTA.ThusitisimportantforclinicaldiagnosisandriskevaluationofCADpatients.【Keywords］High-SensitivityC-ReactiveProtein;Coronaryarterydisease;CTangiography;Riskfactor冠状动脉心脏病危险因素评估对于提早对患者进行干

8、预治疗至关重要。虽然标准的危险因素分级系统已广泛使用，例如Fram