丙型肝炎治疗药物研究与设计

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1、目录丙型肝炎治疗药物研究与设计………………………………………………………3以生命周期划分HCV治疗药物整理………………………………………4HCV的结构………………...……………………………………………4HCV生命周期………………………………………………………...…5以生命周期划分HCV治疗药物整理…………………………..............6总结和展望………………………...…………………………..……….13基于NS5A抑制剂的创新药物设计………………………………………14前言......................................................

2、....................................................14NS5A靶点...............................................................................................14NS5A抑制剂研究进展...........................................................................15BMS-(daclatasvir)研究....................................

3、............................20创新药物设计..........................................................................................24参考文献..................................................................................................26TLR-7激动剂研究与设计………………………………………………….29目前已开发的激动剂........................

4、......................................................29咪唑喹啉胺（imidazoquinolineamine）类..................................291-取代吡唑啉酮（1-SubstitutedPyrazolo(3,4-C)Ring）类......318-氧-去氮嘌呤类/咪唑并吡啶酮类............................................328-羟基腺嘌呤（8-Hydroxyadenine）类......................................3

5、6扩环8-羟基腺嘌呤类..................................................................57艾沙托立宾（Isatoribine）衍生物类..........................................61BitriazolylAcyclonucleoside类...................................................64三氮唑类（Triazole）............................................................

6、.....65嘧啶类（Pyrimidine）.................................................................668-SubstituedBenzoazepines类....................................................68Aminodiazepine类.......................................................................69未来可能的变动空间..................................

7、............................................70创新药物设计..........................................................................................71参考文献....................................................